Cargando…

Proteolysis of HCF-1 by Ser/Thr glycosylation-incompetent O-GlcNAc transferase:UDP-GlcNAc complexes

In complex with the cosubstrate UDP-N-acetylglucosamine (UDP-GlcNAc), O-linked-GlcNAc transferase (OGT) catalyzes Ser/Thr O-GlcNAcylation of many cellular proteins and proteolysis of the transcriptional coregulator HCF-1. Such a dual glycosyltransferase–protease activity, which occurs in the same ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kapuria, Vaibhav, Röhrig, Ute F., Bhuiyan, Tanja, Borodkin, Vladimir S., van Aalten, Daan M.F., Zoete, Vincent, Herr, Winship
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840301/ https://www.ncbi.nlm.nih.gov/pubmed/27056667 http://dx.doi.org/10.1101/gad.275925.115

Ejemplares similares

The conserved threonine-rich region of the HCF-1(PRO) repeat activates promiscuous OGT:UDP-GlcNAc glycosylation and proteolysis activities
por: Kapuria, Vaibhav, et al.
Publicado: (2018)

Thio-Linked UDP–Peptide Conjugates as O-GlcNAc Transferase Inhibitors
por: Rafie, Karim, et al.
Publicado: (2018)

Bisubstrate UDP–peptide conjugates as human O-GlcNAc transferase inhibitors
por: Borodkin, Vladimir S., et al.
Publicado: (2014)

Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats
por: Rafie, Karim, et al.
Publicado: (2017)

Biosynthesis of UDP-GlcNAc, UndPP-GlcNAc and UDP-GlcNAcA Involves Three Easily Distinguished 4-Epimerase Enzymes, Gne, Gnu and GnaB
por: Cunneen, Monica M., et al.
Publicado: (2013)

Structural insights into mechanism and specificity of O-GlcNAc transferase
por: Clarke, Andrew J, et al.
Publicado: (2008)

Proteomic identification of the UDP-GlcNAc: PI α1–6 GlcNAc-transferase subunits of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei
por: Ji, Zhe, et al.
Publicado: (2021)

Substrate and product analogues as human O-GlcNAc transferase inhibitors
por: Dorfmueller, Helge C., et al.
Publicado: (2010)

Arginine glycosylation regulates UDP-GlcNAc biosynthesis in Salmonella enterica
por: El Qaidi, Samir, et al.
Publicado: (2022)

Enzyme-based assay for quantification of UDP-GlcNAc in cells and tissues
por: Chatham, John C., et al.
Publicado: (2023)

Chemical Dissection of the Link between Streptozotocin, O-GlcNAc, and Pancreatic Cell Death
por: Pathak, Shalini, et al.
Publicado: (2008)

X-inactivation normalizes O-GlcNAc transferase levels and generates an O-GlcNAc-depleted Barr body
por: Olivier-Van Stichelen, Stéphanie, et al.
Publicado: (2014)

Feedback Regulation of O-GlcNAc Transferase through Translation Control to Maintain Intracellular O-GlcNAc Homeostasis
por: Lin, Chia-Hung, et al.
Publicado: (2021)

O-GlcNAcase: Promiscuous Hexosaminidase or Key Regulator of O-GlcNAc Signaling?
por: Alonso, Jana, et al.
Publicado: (2014)

Novel roles for GlcNAc in cell signaling
por: Naseem, Shamoon, et al.
Publicado: (2012)

Chemical Arsenal for the Study of O-GlcNAc
por: Kim, Eun J.
Publicado: (2011)

O-GlcNAc as an Integrator of Signaling Pathways
por: Ong, Qunxiang, et al.
Publicado: (2018)

A Conserved Splicing Silencer Dynamically Regulates O-GlcNAc Transferase Intron Retention and O-GlcNAc Homeostasis
por: Park, Sung-Kyun, et al.
Publicado: (2017)

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis
por: Schimpl, Marianne, et al.
Publicado: (2012)

Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins
por: Trapannone, Riccardo, et al.
Publicado: (2016)

Genetically Encoded Green Fluorescent Biosensors for Monitoring UDP-GlcNAc in Live Cells
por: Li, Zefan, et al.
Publicado: (2021)

Genetically Encoded Boronolectin as a Specific Red Fluorescent UDP-GlcNAc Biosensor
por: Zhang, Jing, et al.
Publicado: (2023)

Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability
por: Pravata, Veronica M., et al.
Publicado: (2019)

Dual functionality of O-GlcNAc transferase is required for Drosophila development
por: Mariappa, Daniel, et al.
Publicado: (2015)

O-GlcNAc profiling: from proteins to proteomes
por: Ma, Junfeng, et al.
Publicado: (2014)

O-GlcNAc: A Bittersweet Switch in Liver
por: Zhang, Kaisi, et al.
Publicado: (2014)

Integration of O-GlcNAc into Stress Response Pathways
por: Fahie, Kamau M. M., et al.
Publicado: (2022)

Metabolic Inhibitors of O‐GlcNAc Transferase That Act In Vivo Implicate Decreased O‐GlcNAc Levels in Leptin‐Mediated Nutrient Sensing
por: Liu, Tai‐Wei, et al.
Publicado: (2018)

Bioinformatic prediction of putative conveyers of O-GlcNAc transferase intellectual disability
por: Mitchell, Conor W., et al.
Publicado: (2022)

O-GlcNAcase Expression is Sensitive to Changes in O-GlcNAc Homeostasis
por: Zhang, Zhen, et al.
Publicado: (2014)

Enzymatic assay for UDP-GlcNAc and its application in the parallel assessment of substrate availability and protein O-GlcNAcylation
por: Sunden, Marc, et al.
Publicado: (2023)

O-GlcNAc and aging: C. elegans as a genetic model to test O-GlcNAc roles in type II diabetic insulin resistance
por: Vosseller, Keith
Publicado: (2010)

Engineering the yeast Yarrowia lipolytica for the production of therapeutic proteins homogeneously glycosylated with Man(8)GlcNAc(2) and Man(5)GlcNAc(2)
por: De Pourcq, Karen, et al.
Publicado: (2012)

Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response
por: Liu, Yubo, et al.
Publicado: (2020)

Crystal structure of a UDP-GlcNAc epimerase for surface polysaccharide biosynthesis in Acinetobacter baumannii
por: Shah, Bhumika S., et al.
Publicado: (2018)

Structural snapshots of the reaction coordinate for O-GlcNAc transferase
por: Lazarus, Michael B., et al.
Publicado: (2012)

O-GlcNAc cycling in the developing, adult and geriatric brain
por: Lagerlöf, Olof
Publicado: (2018)

The potential role of O-GlcNAc modification in cancer epigenetics
por: Forma, Ewa, et al.
Publicado: (2014)

The Essential Functions and Detection of Bisecting GlcNAc in Cell Biology
por: Chen, Qiushi, et al.
Publicado: (2020)

Centrosomes: Til O-GlcNAc Do Us Apart
por: Yuan, Aiyun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_glnalhojgrspp6ahh9blu3dbbv