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Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane

The mechanism of Bax/Bak activation remains a central question in mitochondria-dependent apoptotic signaling. While it is established that all proapoptotic Bcl-2 homology 3 (BH3)-only proteins bind and neutralize the anti-apoptotic Bcl-2 family proteins, how this neutralization leads to Bax/Bak acti...

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Detalles Bibliográficos
Autores principales:	O'Neill, Katelyn L., Huang, Kai, Zhang, Jingjing, Chen, Yi, Luo, Xu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840302/ https://www.ncbi.nlm.nih.gov/pubmed/27056669 http://dx.doi.org/10.1101/gad.276725.115

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