Neutrophil Elastase-mediated proteolysis activates the anti-inflammatory cytokine IL-36 Receptor antagonist

The interleukin-36 receptor antagonist (IL-36Ra) which regulates IL-36α, -β and -γ is linked to psoriatic inflammation, especially loss-of-function mutations in pustular psoriasis subtypes. As observed with other IL-1 superfamily proteins, the IL-36 members require N-terminal cleavage for full biolo...

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Detalles Bibliográficos
Autores principales: Macleod, Tom, Doble, Rosella, McGonagle, Dennis, Wasson, Christopher W., Alase, Adewonuola, Stacey, Martin, Wittmann, Miriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840362/
https://www.ncbi.nlm.nih.gov/pubmed/27101808
http://dx.doi.org/10.1038/srep24880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840362/
https://www.ncbi.nlm.nih.gov/pubmed/27101808
http://dx.doi.org/10.1038/srep24880

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