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Neutrophil Elastase-mediated proteolysis activates the anti-inflammatory cytokine IL-36 Receptor antagonist

The interleukin-36 receptor antagonist (IL-36Ra) which regulates IL-36α, -β and -γ is linked to psoriatic inflammation, especially loss-of-function mutations in pustular psoriasis subtypes. As observed with other IL-1 superfamily proteins, the IL-36 members require N-terminal cleavage for full biolo...

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Detalles Bibliográficos
Autores principales:	Macleod, Tom, Doble, Rosella, McGonagle, Dennis, Wasson, Christopher W., Alase, Adewonuola, Stacey, Martin, Wittmann, Miriam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840362/ https://www.ncbi.nlm.nih.gov/pubmed/27101808 http://dx.doi.org/10.1038/srep24880

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