Cargando…
Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles
We previously investigated the utility of μ-oxo N,N′- bis(salicylidene)ethylenediamine iron (Fe(Salen)) nanoparticles as a new anti-cancer agent for magnet-guided delivery with anti-cancer activity. Fe(Salen) nanoparticles should rapidly heat up in an alternating magnetic field (AMF), and we hypothe...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840378/ https://www.ncbi.nlm.nih.gov/pubmed/27103308 http://dx.doi.org/10.1038/srep24629 |
_version_ | 1782428274264113152 |
---|---|
author | Sato, Itaru Umemura, Masanari Mitsudo, Kenji Fukumura, Hidenobu Kim, Jeong-Hwan Hoshino, Yujiro Nakashima, Hideyuki Kioi, Mitomu Nakakaji, Rina Sato, Motohiko Fujita, Takayuki Yokoyama, Utako Okumura, Satoshi Oshiro, Hisashi Eguchi, Haruki Tohnai, Iwai Ishikawa, Yoshihiro |
author_facet | Sato, Itaru Umemura, Masanari Mitsudo, Kenji Fukumura, Hidenobu Kim, Jeong-Hwan Hoshino, Yujiro Nakashima, Hideyuki Kioi, Mitomu Nakakaji, Rina Sato, Motohiko Fujita, Takayuki Yokoyama, Utako Okumura, Satoshi Oshiro, Hisashi Eguchi, Haruki Tohnai, Iwai Ishikawa, Yoshihiro |
author_sort | Sato, Itaru |
collection | PubMed |
description | We previously investigated the utility of μ-oxo N,N′- bis(salicylidene)ethylenediamine iron (Fe(Salen)) nanoparticles as a new anti-cancer agent for magnet-guided delivery with anti-cancer activity. Fe(Salen) nanoparticles should rapidly heat up in an alternating magnetic field (AMF), and we hypothesized that these single-drug nanoparticles would be effective for combined hyperthermia-chemotherapy. Conventional hyperthermic particles are usually made of iron oxide, and thus cannot exhibit anti-cancer activity in the absence of an AMF. We found that Fe(Salen) nanoparticles induced apoptosis in cultured cancer cells, and that AMF exposure enhanced the apoptotic effect. Therefore, we evaluated the combined three-fold strategy, i.e., chemotherapy with Fe(Salen) nanoparticles, magnetically guided delivery of the nanoparticles to the tumor, and AMF-induced heating of the nanoparticles to induce local hyperthermia, in a rabbit model of tongue cancer. Intravenous administration of Fe(Salen) nanoparticles per se inhibited tumor growth before the other two modalities were applied. This inhibition was enhanced when a magnet was used to accumulate Fe(Salen) nanoparticles at the tongue. When an AMF was further applied (magnet-guided chemotherapy plus hyperthermia), the tumor masses were dramatically reduced. These results indicate that our strategy of combined hyperthermia-chemotherapy using Fe(Salen) nanoparticles specifically delivered with magnetic guidance represents a powerful new approach for cancer treatment. |
format | Online Article Text |
id | pubmed-4840378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48403782016-04-28 Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles Sato, Itaru Umemura, Masanari Mitsudo, Kenji Fukumura, Hidenobu Kim, Jeong-Hwan Hoshino, Yujiro Nakashima, Hideyuki Kioi, Mitomu Nakakaji, Rina Sato, Motohiko Fujita, Takayuki Yokoyama, Utako Okumura, Satoshi Oshiro, Hisashi Eguchi, Haruki Tohnai, Iwai Ishikawa, Yoshihiro Sci Rep Article We previously investigated the utility of μ-oxo N,N′- bis(salicylidene)ethylenediamine iron (Fe(Salen)) nanoparticles as a new anti-cancer agent for magnet-guided delivery with anti-cancer activity. Fe(Salen) nanoparticles should rapidly heat up in an alternating magnetic field (AMF), and we hypothesized that these single-drug nanoparticles would be effective for combined hyperthermia-chemotherapy. Conventional hyperthermic particles are usually made of iron oxide, and thus cannot exhibit anti-cancer activity in the absence of an AMF. We found that Fe(Salen) nanoparticles induced apoptosis in cultured cancer cells, and that AMF exposure enhanced the apoptotic effect. Therefore, we evaluated the combined three-fold strategy, i.e., chemotherapy with Fe(Salen) nanoparticles, magnetically guided delivery of the nanoparticles to the tumor, and AMF-induced heating of the nanoparticles to induce local hyperthermia, in a rabbit model of tongue cancer. Intravenous administration of Fe(Salen) nanoparticles per se inhibited tumor growth before the other two modalities were applied. This inhibition was enhanced when a magnet was used to accumulate Fe(Salen) nanoparticles at the tongue. When an AMF was further applied (magnet-guided chemotherapy plus hyperthermia), the tumor masses were dramatically reduced. These results indicate that our strategy of combined hyperthermia-chemotherapy using Fe(Salen) nanoparticles specifically delivered with magnetic guidance represents a powerful new approach for cancer treatment. Nature Publishing Group 2016-04-22 /pmc/articles/PMC4840378/ /pubmed/27103308 http://dx.doi.org/10.1038/srep24629 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Sato, Itaru Umemura, Masanari Mitsudo, Kenji Fukumura, Hidenobu Kim, Jeong-Hwan Hoshino, Yujiro Nakashima, Hideyuki Kioi, Mitomu Nakakaji, Rina Sato, Motohiko Fujita, Takayuki Yokoyama, Utako Okumura, Satoshi Oshiro, Hisashi Eguchi, Haruki Tohnai, Iwai Ishikawa, Yoshihiro Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles |
title | Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles |
title_full | Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles |
title_fullStr | Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles |
title_full_unstemmed | Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles |
title_short | Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles |
title_sort | simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840378/ https://www.ncbi.nlm.nih.gov/pubmed/27103308 http://dx.doi.org/10.1038/srep24629 |
work_keys_str_mv | AT satoitaru simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles AT umemuramasanari simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles AT mitsudokenji simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles AT fukumurahidenobu simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles AT kimjeonghwan simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles AT hoshinoyujiro simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles AT nakashimahideyuki simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles AT kioimitomu simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles AT nakakajirina simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles AT satomotohiko simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles AT fujitatakayuki simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles AT yokoyamautako simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles AT okumurasatoshi simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles AT oshirohisashi simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles AT eguchiharuki simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles AT tohnaiiwai simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles AT ishikawayoshihiro simultaneoushyperthermiachemotherapywithcontrolleddrugdeliveryusingsingledrugnanoparticles |