Cargando…

The bromodomain inhibitor N-methyl pyrrolidone reduced fat accumulation in an ovariectomized rat model

BACKGROUND: Weight gain is one of the consequences of estrogen deficiency and constitutes a major health problem. The present study highlights the effects of N-methyl pyrrolidone (NMP) on adipogenesis in osteoporosis induced by estrogen deficiency in an ovariectomized rat model. RESULTS: Ovariectomy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gjoksi, Bebeka, Ghayor, Chafik, Bhattacharya, Indranil, Zenobi-Wong, Marcy, Weber, Franz E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840488/ https://www.ncbi.nlm.nih.gov/pubmed/27110299 http://dx.doi.org/10.1186/s13148-016-0209-2

Ejemplares similares

The Bromodomain Inhibitor N-Methyl pyrrolidone Prevents Osteoporosis and BMP-Triggered Sclerostin Expression in Osteocytes
por: Siegenthaler, Barbara, et al.
Publicado: (2018)

N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment
por: Ghayor, Chafik, et al.
Publicado: (2017)

Effect of N-Vinyl-2-Pyrrolidone (NVP), a Bromodomain-Binding Small Chemical, on Osteoblast and Osteoclast Differentiation and Its Potential Application for Bone Regeneration
por: Klemmer, Viviane A., et al.
Publicado: (2021)

N,N-Dimethlyacetamide Prevents the High-Fat Diet-Induced Increase in Body Weight
por: Bhattacharya, Indranil, et al.
Publicado: (2019)

The Release of the Bromodomain Ligand N,N-Dimethylacetamide Adds Bioactivity to a Resorbable Guided Bone Regeneration Membrane in a Rabbit Calvarial Defect Model
por: Siegenthaler, Barbara, et al.
Publicado: (2020)

Osteoconductivity of bone substitutes with filament-based microarchitectures: Influence of directionality, filament dimension, and distance
por: Guerrero, Julien, et al.
Publicado: (2022)

From Influenza Virus to Novel Corona Virus (SARS-CoV-2)–The Contribution of Obesity
por: Bhattacharya, Indranil, et al.
Publicado: (2020)

3D-Printed HA-Based Scaffolds for Bone Regeneration: Microporosity, Osteoconduction and Osteoclastic Resorption
por: Ghayor, Chafik, et al.
Publicado: (2022)

Influence of Scaffold Microarchitecture on Angiogenesis and Regulation of Cell Differentiation during the Early Phase of Bone Healing: A Transcriptomics and Histological Analysis
por: Guerrero, Julien, et al.
Publicado: (2023)

Triply Periodic Minimal Surface-Based Scaffolds for Bone Tissue Engineering: A Mechanical, In Vitro and In Vivo Study
por: Maevskaia, Ekaterina, et al.
Publicado: (2023)

Microporosities in 3D-Printed Tricalcium-Phosphate-Based Bone Substitutes Enhance Osteoconduction and Affect Osteoclastic Resorption
por: Ghayor, Chafik, et al.
Publicado: (2020)

Epigenetic Regulation of Bone Remodeling and Its Impacts in Osteoporosis
por: Ghayor, Chafik, et al.
Publicado: (2016)

Osteoconductive Microarchitecture of Bone Substitutes for Bone Regeneration Revisited
por: Ghayor, Chafik, et al.
Publicado: (2018)

N-Methyl-2-Pyrrolidone
Publicado: (2001)

Fibrin Hydrogel Based Bone Substitute Tethered with BMP-2 and BMP-2/7 Heterodimers
por: Karfeld-Sulzer, Lindsay S., et al.
Publicado: (2015)

Pulp-Derived Exosomes in a Fibrin-Based Regenerative Root Filling Material
por: Ivica, Anja, et al.
Publicado: (2020)

Physicochemical Characterization of Polyvinyl Pyrrolidone: A Tale of Two Polyvinyl Pyrrolidones
por: Mireles, Laura Karina, et al.
Publicado: (2020)

Effects of Melatonin Supplementation on Lipid Metabolism and Body Fat Accumulation in Ovariectomized Rats
por: Hsu, Ling-Wen, et al.
Publicado: (2023)

Reversible Contraceptive Potential of FDA Approved Excipient N, N-Dimethylacetamide in Male Rats
por: Khera, Nupur, et al.
Publicado: (2020)

Green alternative cosolvents to N-methyl-2-pyrrolidone in water polyurethane dispersions
por: Germán, Lorena, et al.
Publicado: (2021)

On the Properties of Nafion Membranes Recast from Dispersion in N-Methyl-2-Pyrrolidone
por: Safronova, Ekaterina Yu., et al.
Publicado: (2022)

Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice
por: Shim, Ki-Shuk, et al.
Publicado: (2020)

Effects of Dietary Fatty Acid Composition on Lipid Metabolism and Body Fat Accumulation in Ovariectomized Rats
por: Yeh, Jhih-Han, et al.
Publicado: (2021)

Enhancement of Mycophenolate Mofetil Permeation for Topical Use by Eucalyptol and N-Methyl-2-pyrrolidone
por: Amnuaikit, Thanaporn, et al.
Publicado: (2016)

Regeneration – A New Therapeutic Dimension in Otorhinolaryngology
por: Rotter, Nicole, et al.
Publicado: (2018)

Three-Dimensional Printed Hydroxyapatite Bone Substitutes Designed by a Novel Periodic Minimal Surface Algorithm Are Highly Osteoconductive
por: Maevskaia, Ekaterina, et al.
Publicado: (2023)

Lattice Microarchitecture for Bone Tissue Engineering from Calcium Phosphate Compared to Titanium
por: Chen, Tse-Hsiang, et al.
Publicado: (2018)

BET bromodomain inhibitors synergize with ATR inhibitors in melanoma
por: Veppil Muralidharan, Somsundar, et al.
Publicado: (2017)

BET bromodomain inhibitors synergize with ATR inhibitors in melanoma
por: Muralidharan, Somsundar Veppil, et al.
Publicado: (2017)

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family
por: Filippakopoulos, Panagis, et al.
Publicado: (2012)

N-Methyl Pyrrolidone (NMP) Alleviates Lipopolysaccharide (LPS)-Induced Inflammatory Injury in Articular Chondrocytes
por: Zhu, Xianping, et al.
Publicado: (2018)

Thermodynamic Assessment of Triclocarban Dissolution Process in N-Methyl-2-pyrrolidone + Water Cosolvent Mixtures
por: Caviedes-Rubio, Diego Ivan, et al.
Publicado: (2023)

Antifungal and Antioxidant Activities of Pyrrolidone Thiosemicarbazone Complexes
por: Al-Amiery, Ahmed A., et al.
Publicado: (2012)

Inhibitors of bromodomain and extra‐terminal proteins for treating multiple human diseases
por: Kulikowski, Ewelina, et al.
Publicado: (2020)

Metabolism of JQ1, an inhibitor of bromodomain and extra terminal bromodomain proteins, in human and mouse liver microsomes
por: Li, Feng, et al.
Publicado: (2020)

The European Human Biomonitoring Initiative (HBM4EU): Human biomonitoring guidance values (HBM-GVs) for the aprotic solvents N-methyl-2-pyrrolidone (NMP) and N-ethyl-2-pyrrolidone (NEP)
por: David, Madlen, et al.
Publicado: (2021)

Correction: The Flavonoid Isoquercitrin Promotes Neurite Elongation by Reducing RhoA Activity
por: Palazzolo, Gemma, et al.
Publicado: (2012)

The Flavonoid Isoquercitrin Promotes Neurite Elongation by Reducing RhoA Activity
por: Palazzolo, Gemma, et al.
Publicado: (2012)

Glucose‐dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice
por: Shimazu‐Kuwahara, Satoko, et al.
Publicado: (2018)

Considerations for spectroscopy of liquid-exfoliated 2D materials: emerging photoluminescence of N-methyl-2-pyrrolidone
por: Ogilvie, Sean P., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_22ou68v91lnni1vfv6n2o9v7q4