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Outcome of patients with glioblastoma in Saudi Arabia: Single center experience

Glioblastoma multiforme (GBM), the most common primary brain tumor in adults, is associated with one of the worst 5 year survival rates among all human cancer types. To date, no published data are available for the outcome of this disease in Saudi Arabia. The present study performed a single-center,...

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Autores principales: ALTWAIRGI, ABDULLAH K., ALGAREEB, WALEED, YAHYA, GAAEM, MAKLAD, AHMED M., ALY, MOAMEN MOM, AL SHAKWEER, WAFA, BALBAID, ALI, ALSAEED, EYAD, ALHUSSAIN, HUSSAIN, ORZ, YASSIR, LARY, AHMED, ELYAMANY, ASHRAF
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840558/
https://www.ncbi.nlm.nih.gov/pubmed/27123275
http://dx.doi.org/10.3892/mco.2016.818
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author ALTWAIRGI, ABDULLAH K.
ALGAREEB, WALEED
YAHYA, GAAEM
MAKLAD, AHMED M.
ALY, MOAMEN MOM
AL SHAKWEER, WAFA
BALBAID, ALI
ALSAEED, EYAD
ALHUSSAIN, HUSSAIN
ORZ, YASSIR
LARY, AHMED
ELYAMANY, ASHRAF
author_facet ALTWAIRGI, ABDULLAH K.
ALGAREEB, WALEED
YAHYA, GAAEM
MAKLAD, AHMED M.
ALY, MOAMEN MOM
AL SHAKWEER, WAFA
BALBAID, ALI
ALSAEED, EYAD
ALHUSSAIN, HUSSAIN
ORZ, YASSIR
LARY, AHMED
ELYAMANY, ASHRAF
author_sort ALTWAIRGI, ABDULLAH K.
collection PubMed
description Glioblastoma multiforme (GBM), the most common primary brain tumor in adults, is associated with one of the worst 5 year survival rates among all human cancer types. To date, no published data are available for the outcome of this disease in Saudi Arabia. The present study performed a single-center, retrospective cohort study to evaluate the outcome of patients with GBM in Saudi Arabia. The Comprehensive Cancer Center at King Fahad Medical city (Riyadh, Saudi Arabia) was used in the present study. All adult patients (≥18 years) diagnosed with histologically proven GBM between January 2008 and December 2013 were included in the present study. A total of 90 patients were treated during the specified period. Of this, 73 (81%) patients underwent resection and 17 (19%) had biopsy only. The majority of patients (n=88; 98%) received radiotherapy (XRT): 67 (76%) with standard and 21 (24%) with hypo-fractionated dosage. Of the total patients, 65 (72%) received combined modality therapy [standard XRT concurrently with Temozolmide (TMZ)]. The 6 month progression-free survival rate was 43% for all patients and 55% for the combined modality subgroup. The median overall survival (OS) for all patients was 13.7 months. However, the median OS for patients treated with combined modality was 19.7 months. In this single-center retrospective study, the outcomes of patients with GBM were similar to those in previously reported studies. An improved outcome was associated with an improved performance status, absence of residual disease and use of adjuvant TMZ.
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spelling pubmed-48405582016-04-27 Outcome of patients with glioblastoma in Saudi Arabia: Single center experience ALTWAIRGI, ABDULLAH K. ALGAREEB, WALEED YAHYA, GAAEM MAKLAD, AHMED M. ALY, MOAMEN MOM AL SHAKWEER, WAFA BALBAID, ALI ALSAEED, EYAD ALHUSSAIN, HUSSAIN ORZ, YASSIR LARY, AHMED ELYAMANY, ASHRAF Mol Clin Oncol Articles Glioblastoma multiforme (GBM), the most common primary brain tumor in adults, is associated with one of the worst 5 year survival rates among all human cancer types. To date, no published data are available for the outcome of this disease in Saudi Arabia. The present study performed a single-center, retrospective cohort study to evaluate the outcome of patients with GBM in Saudi Arabia. The Comprehensive Cancer Center at King Fahad Medical city (Riyadh, Saudi Arabia) was used in the present study. All adult patients (≥18 years) diagnosed with histologically proven GBM between January 2008 and December 2013 were included in the present study. A total of 90 patients were treated during the specified period. Of this, 73 (81%) patients underwent resection and 17 (19%) had biopsy only. The majority of patients (n=88; 98%) received radiotherapy (XRT): 67 (76%) with standard and 21 (24%) with hypo-fractionated dosage. Of the total patients, 65 (72%) received combined modality therapy [standard XRT concurrently with Temozolmide (TMZ)]. The 6 month progression-free survival rate was 43% for all patients and 55% for the combined modality subgroup. The median overall survival (OS) for all patients was 13.7 months. However, the median OS for patients treated with combined modality was 19.7 months. In this single-center retrospective study, the outcomes of patients with GBM were similar to those in previously reported studies. An improved outcome was associated with an improved performance status, absence of residual disease and use of adjuvant TMZ. D.A. Spandidos 2016-05 2016-03-10 /pmc/articles/PMC4840558/ /pubmed/27123275 http://dx.doi.org/10.3892/mco.2016.818 Text en Copyright: © Altwairgi et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
ALTWAIRGI, ABDULLAH K.
ALGAREEB, WALEED
YAHYA, GAAEM
MAKLAD, AHMED M.
ALY, MOAMEN MOM
AL SHAKWEER, WAFA
BALBAID, ALI
ALSAEED, EYAD
ALHUSSAIN, HUSSAIN
ORZ, YASSIR
LARY, AHMED
ELYAMANY, ASHRAF
Outcome of patients with glioblastoma in Saudi Arabia: Single center experience
title Outcome of patients with glioblastoma in Saudi Arabia: Single center experience
title_full Outcome of patients with glioblastoma in Saudi Arabia: Single center experience
title_fullStr Outcome of patients with glioblastoma in Saudi Arabia: Single center experience
title_full_unstemmed Outcome of patients with glioblastoma in Saudi Arabia: Single center experience
title_short Outcome of patients with glioblastoma in Saudi Arabia: Single center experience
title_sort outcome of patients with glioblastoma in saudi arabia: single center experience
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840558/
https://www.ncbi.nlm.nih.gov/pubmed/27123275
http://dx.doi.org/10.3892/mco.2016.818
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