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Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review

The β-lactamase inhibitor, clavulanic acid is frequently used in combination with β-lactam antibiotics to treat a wide spectrum of infectious diseases. Clavulanic acid prevents drug resistance by pathogens against these β-lactam antibiotics by preventing the degradation of the β-lactam ring, thus en...

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Autores principales: Ser, Hooi-Leng, Law, Jodi Woan-Fei, Chaiyakunapruk, Nathorn, Jacob, Sabrina Anne, Palanisamy, Uma Devi, Chan, Kok-Gan, Goh, Bey-Hing, Lee, Learn-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840625/
https://www.ncbi.nlm.nih.gov/pubmed/27148211
http://dx.doi.org/10.3389/fmicb.2016.00522
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author Ser, Hooi-Leng
Law, Jodi Woan-Fei
Chaiyakunapruk, Nathorn
Jacob, Sabrina Anne
Palanisamy, Uma Devi
Chan, Kok-Gan
Goh, Bey-Hing
Lee, Learn-Han
author_facet Ser, Hooi-Leng
Law, Jodi Woan-Fei
Chaiyakunapruk, Nathorn
Jacob, Sabrina Anne
Palanisamy, Uma Devi
Chan, Kok-Gan
Goh, Bey-Hing
Lee, Learn-Han
author_sort Ser, Hooi-Leng
collection PubMed
description The β-lactamase inhibitor, clavulanic acid is frequently used in combination with β-lactam antibiotics to treat a wide spectrum of infectious diseases. Clavulanic acid prevents drug resistance by pathogens against these β-lactam antibiotics by preventing the degradation of the β-lactam ring, thus ensuring eradication of these harmful microorganisms from the host. This systematic review provides an overview on the fermentation conditions that affect the production of clavulanic acid in the firstly described producer, Streptomyces clavuligerus. A thorough search was conducted using predefined terms in several electronic databases (PubMed, Medline, ScienceDirect, EBSCO), from database inception to June 30th 2015. Studies must involve wild-type Streptomyces clavuligerus, and full texts needed to be available. A total of 29 eligible articles were identified. Based on the literature, several factors were identified that could affect the production of clavulanic acid in S. clavuligerus. The addition of glycerol or other vegetable oils (e.g., olive oil, corn oil) could potentially affect clavulanic acid production. Furthermore, some amino acids such as arginine and ornithine, could serve as potential precursors to increase clavulanic acid yield. The comparison of different fermentation systems revealed that fed-batch fermentation yields higher amounts of clavulanic acid as compared to batch fermentation, probably due to the maintenance of substrates and constant monitoring of certain entities (such as pH, oxygen availability, etc.). Overall, these findings provide vital knowledge and insight that could assist media optimization and fermentation design for clavulanic acid production in S. clavuligerus.
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spelling pubmed-48406252016-05-04 Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review Ser, Hooi-Leng Law, Jodi Woan-Fei Chaiyakunapruk, Nathorn Jacob, Sabrina Anne Palanisamy, Uma Devi Chan, Kok-Gan Goh, Bey-Hing Lee, Learn-Han Front Microbiol Microbiology The β-lactamase inhibitor, clavulanic acid is frequently used in combination with β-lactam antibiotics to treat a wide spectrum of infectious diseases. Clavulanic acid prevents drug resistance by pathogens against these β-lactam antibiotics by preventing the degradation of the β-lactam ring, thus ensuring eradication of these harmful microorganisms from the host. This systematic review provides an overview on the fermentation conditions that affect the production of clavulanic acid in the firstly described producer, Streptomyces clavuligerus. A thorough search was conducted using predefined terms in several electronic databases (PubMed, Medline, ScienceDirect, EBSCO), from database inception to June 30th 2015. Studies must involve wild-type Streptomyces clavuligerus, and full texts needed to be available. A total of 29 eligible articles were identified. Based on the literature, several factors were identified that could affect the production of clavulanic acid in S. clavuligerus. The addition of glycerol or other vegetable oils (e.g., olive oil, corn oil) could potentially affect clavulanic acid production. Furthermore, some amino acids such as arginine and ornithine, could serve as potential precursors to increase clavulanic acid yield. The comparison of different fermentation systems revealed that fed-batch fermentation yields higher amounts of clavulanic acid as compared to batch fermentation, probably due to the maintenance of substrates and constant monitoring of certain entities (such as pH, oxygen availability, etc.). Overall, these findings provide vital knowledge and insight that could assist media optimization and fermentation design for clavulanic acid production in S. clavuligerus. Frontiers Media S.A. 2016-04-22 /pmc/articles/PMC4840625/ /pubmed/27148211 http://dx.doi.org/10.3389/fmicb.2016.00522 Text en Copyright © 2016 Ser, Law, Chaiyakunapruk, Jacob, Palanisamy, Chan, Goh and Lee. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Ser, Hooi-Leng
Law, Jodi Woan-Fei
Chaiyakunapruk, Nathorn
Jacob, Sabrina Anne
Palanisamy, Uma Devi
Chan, Kok-Gan
Goh, Bey-Hing
Lee, Learn-Han
Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review
title Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review
title_full Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review
title_fullStr Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review
title_full_unstemmed Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review
title_short Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review
title_sort fermentation conditions that affect clavulanic acid production in streptomyces clavuligerus: a systematic review
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840625/
https://www.ncbi.nlm.nih.gov/pubmed/27148211
http://dx.doi.org/10.3389/fmicb.2016.00522
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