Cargando…

TLR7 agonist induced repression of hepatocellular carcinoma via the TLR7-IKK-NF-κB-IL6 signaling pathway

Toll-like receptors (TLRs) are key members of innate immunity, involved in the defense against diseases, and evidence has revealed that TLR4/5 is involved in the carcinogenesis of hepatic cancer. TLR7 belongs to the TLR family, and its roles in immune-associated hepatic diseases have been well chara...

Descripción completa

Detalles Bibliográficos
Autores principales:	REN, XINGBIN, WANG, FEI, JI, BAOJU, GAO, CHUNHAI
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840696/ https://www.ncbi.nlm.nih.gov/pubmed/27123047 http://dx.doi.org/10.3892/ol.2016.4329

Ejemplares similares

Deoxyguanosine is a TLR7 agonist
por: Davenne, Tamara, et al.
Publicado: (2019)

The Effect and Mechanism of KLF7 in the TLR4/NF-κB/IL-6 Inflammatory Signal Pathway of Adipocytes
por: Zhang, Meixiu, et al.
Publicado: (2018)

Comparison of human B cell activation by TLR7 and TLR9 agonists
por: Hanten, John A, et al.
Publicado: (2008)

Trial Watch: experimental TLR7/TLR8 agonists for oncological indications
por: Frega, Giorgio, et al.
Publicado: (2020)

Roles of TLR7 in Activation of NF-κB Signaling of Keratinocytes by Imiquimod
por: Li, Zheng Jun, et al.
Publicado: (2013)

The role of TLR7 agonists in modulating COVID-19 severity in subjects with loss-of-function TLR7 variants
por: Naushad, Shaik Mohammad, et al.
Publicado: (2023)

Molecular dynamics simulations reveal the selectivity mechanism of structurally similar agonists to TLR7 and TLR8
por: Wang, Xiaoyu, et al.
Publicado: (2022)

Cytokine Effect of TLR3, TLR4, and TLR7 Agonists Alone or Associated with Leishmania infantum Antigen on Blood from Dogs
por: Martínez-Orellana, Pamela, et al.
Publicado: (2018)

Innate Immune Receptors in Human Airway Smooth Muscle Cells: Activation by TLR1/2, TLR3, TLR4, TLR7 and NOD1 Agonists
por: Månsson Kvarnhammar, Anne, et al.
Publicado: (2013)

Potent Adjuvanticity of a Pure TLR7-Agonistic Imidazoquinoline Dendrimer
por: Shukla, Nikunj M., et al.
Publicado: (2012)

Intratumoral immunotherapy with the TLR7/8 agonist 3M-052
por: Smirnov, DV, et al.
Publicado: (2013)

The TLR7 agonist Imiquimod promote the immunogenicity of msenchymal stem cells
por: Zhang, Li, et al.
Publicado: (2015)

Differential Adjuvant Activities of TLR7 and TLR9 Agonists Inversely Correlate with Nitric Oxide and PGE(2) Production
por: Lee, Jinhee, et al.
Publicado: (2015)

Distinct trans-placental effects of maternal immune activation by TLR3 and TLR7 agonists: implications for schizophrenia risk
por: Kwon, Jaedeok, et al.
Publicado: (2021)

Expression of TLR2, TLR3, TLR4, and TLR7 on pulmonary lymphocytes of Schistosoma japonicum-infected C57BL/6 mice
por: Chen, Dianhui, et al.
Publicado: (2019)

Pharmacological Activation of p53 during Human Monocyte to Macrophage Differentiation Attenuates Their Pro-Inflammatory Activation by TLR4, TLR7 and TLR8 Agonists
por: Namgaladze, Dmitry, et al.
Publicado: (2021)

Importance of extra- and intracellular domains of TLR1 and TLR2 in NFκB signaling
por: Sandor, Frantisek, et al.
Publicado: (2003)

Conjugate of ibrutinib with a TLR7 agonist suppresses melanoma progression and enhances antitumor immunity
por: Ren, Sumei, et al.
Publicado: (2022)

Xuebijing injection protects sepsis induced myocardial injury by mediating TLR4/NF-κB/IKKα and JAK2/STAT3 signaling pathways
por: Kang, Xiang-Fei, et al.
Publicado: (2023)

Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists
por: Birmachu, Woubalem, et al.
Publicado: (2007)

Stimulation of Innate Immune Cells by Light-Activated TLR7/8 Agonists
por: Ryu, Keun Ah, et al.
Publicado: (2014)

Immunomodulatory and Antitumor Effects of a Novel TLR7 Agonist Combined with Lapatinib
por: Gao, Ningning, et al.
Publicado: (2016)

Antibody and TLR7 Agonist Delay Viral Rebound in SHIV-Infected Monkeys
por: Borducchi, Erica N., et al.
Publicado: (2018)

Rational design of antisense oligonucleotides modulating the activity of TLR7/8 agonists
por: Alharbi, Arwaf S, et al.
Publicado: (2020)

BBIQ, a pure TLR7 agonist, is an effective influenza vaccine adjuvant
por: Kaushik, Deepender, et al.
Publicado: (2020)

Synthesis and immunopharmacological evaluation of novel TLR7 agonistic triazole tethered imidazoquinolines
por: Avoni, Ayyappa, et al.
Publicado: (2023)

Combination of STING and TLR 7/8 Agonists as Vaccine Adjuvants for Cancer Immunotherapy
por: Bhatnagar, Shubhmita, et al.
Publicado: (2022)

HDAC7 Activates IKK/NF-κB Signaling to Regulate Astrocyte-Mediated Inflammation
por: Ye, Jinwang, et al.
Publicado: (2022)

7α-Hydroxycholesterol Elicits TLR6-Mediated Expression of IL-23 in Monocytic Cells
por: Seo, Hyun Chul, et al.
Publicado: (2015)

TLR4 Agonist and Hypoxia Synergistically Promote the Formation of TLR4/NF-κB/HIF-1α Loop in Human Epithelial Ovarian Cancer
por: Zhao, Bin, et al.
Publicado: (2022)

Alum and a TLR7 agonist combined with built-in TLR4 and 5 agonists synergistically enhance immune responses against HPV RG1 epitope
por: Mashhadi Abolghasem Shirazi, Maryam, et al.
Publicado: (2023)

Oleanolic Acid Acetate Exerts Anti-Inflammatory Activity via IKKα/β Suppression in TLR3-Mediated NF-κB Activation
por: Lim, Hyung Jin, et al.
Publicado: (2019)

Toll-like Receptor 7 (TLR7) Is Expressed in Adipocytes and the Pharmacological TLR7 Agonist Imiquimod and Adipocyte-Derived Cell-Free Nucleic Acids (cfDNA) Regulate Adipocyte Function
por: Thomalla, Miriam, et al.
Publicado: (2022)

LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF
por: Fitzgerald, Katherine A., et al.
Publicado: (2003)

TLR7 promotes skin inflammation via activating NFκB-mTORC1 axis in rosacea
por: Huang, Yaqun, et al.
Publicado: (2023)

Whole blood targeting and activation of monocytes with TLR7 agonist formulated in cationic liposomes
por: Jensen, Simon S, et al.
Publicado: (2013)

Tolerability in man following inhalation dosing of the selective TLR7 agonist, AZD8848
por: Delaney, Stephen, et al.
Publicado: (2016)

High potency of lipid conjugated TLR7 agonist requires nanoparticulate or liposomal formulation
por: Gadd, Adam J.R., et al.
Publicado: (2018)

Development of Adamantane-Conjugated TLR7/8 Agonists for Supramolecular Delivery and Cancer Immunotherapy
por: Rodell, Christopher B., et al.
Publicado: (2019)

STING and TLR7/8 agonists-based nanovaccines for synergistic antitumor immune activation
por: Zhang, Bo-Dou, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_23luog5edjjl7hojvjvj8os0lk