A novel antagonist of p75NTR reduces peripheral expansion and CNS trafficking of pro-inflammatory monocytes and spares function after traumatic brain injury

BACKGROUND: Traumatic brain injury (TBI) results in long-term neurological deficits, which may be mediated in part by pro-inflammatory responses in both the injured brain and the circulation. Inflammation may be involved in the subsequent development of neurodegenerative diseases and post-injury sei...

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Detalles Bibliográficos
Autores principales: Lee, Sangmi, Mattingly, Aaron, Lin, Amity, Sacramento, Jeffrey, Mannent, Leda, Castel, Marie-Noelle, Canolle, Benoit, Delbary-Gossart, Sandrine, Ferzaz, Badia, Morganti, Josh M., Rosi, Susanna, Ferguson, Adam R., Manley, Geoffrey T., Bresnahan, Jacqueline C., Beattie, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840857/
https://www.ncbi.nlm.nih.gov/pubmed/27102880
http://dx.doi.org/10.1186/s12974-016-0544-4

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