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Empirical estimation of sequencing error rates using smoothing splines

BACKGROUND: Next-generation sequencing has been used by investigators to address a diverse range of biological problems through, for example, polymorphism and mutation discovery and microRNA profiling. However, compared to conventional sequencing, the error rates for next-generation sequencing are o...

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Detalles Bibliográficos
Autores principales: Zhu, Xuan, Wang, Jian, Peng, Bo, Shete, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840868/
https://www.ncbi.nlm.nih.gov/pubmed/27102907
http://dx.doi.org/10.1186/s12859-016-1052-3