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Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia
OBJECTIVES: Links between endorphins and dopaminergic transmission have not been fully explored in schizophrenia. Both endorphins excess and deficiency were postulated. CGRP is probably involved in dopaminergic transmission. The aim of this study was the evaluation of beta-endorphin (BE) and CGRP bl...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841412/ https://www.ncbi.nlm.nih.gov/pubmed/27143887 http://dx.doi.org/10.2147/NDT.S101647 |
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author | Urban-Kowalczyk, Małgorzata Śmigielski, Janusz Strzelecki, Dominik |
author_facet | Urban-Kowalczyk, Małgorzata Śmigielski, Janusz Strzelecki, Dominik |
author_sort | Urban-Kowalczyk, Małgorzata |
collection | PubMed |
description | OBJECTIVES: Links between endorphins and dopaminergic transmission have not been fully explored in schizophrenia. Both endorphins excess and deficiency were postulated. CGRP is probably involved in dopaminergic transmission. The aim of this study was the evaluation of beta-endorphin (BE) and CGRP blood concentrations before and after treatment of severe schizophrenia. METHODS: Seventy patients treated with various antipsychotics, with severe symptoms of schizophrenia (51 with positive symptoms, 19 with negative symptoms), 15 first-degree relatives, and 44 healthy controls were included in the study. BE and CGRP blood concentrations were measured during patients severe schizophrenia and in their stable mental state after treatment. The results were compared with relatives and controls. RESULTS: BE and CGRP concentrations in patients with negative symptoms were higher than in relatives and in controls. BE levels in patients with positive symptoms were lower than in patients with negative symptoms (P<0.0000) and controls (P<0.0006). No significant changes in CGRP concentration were found in patient samples. CGRP levels in these samples were independent of treatment, but they were significantly higher than in relatives and controls. After the treatment, BE level decreased in patients with negative symptoms (P<0.0001) and increased in patients with positive symptoms (P<0.0000). No differences in BE concentration between patients in stable mental state, their relatives, and controls were found. CONCLUSION: Effective antipsychotic treatment results in “normalization” of BE level. Specific changes in BE concentration could be involved in dopaminergic transmission and related to some symptoms of schizophrenia. |
format | Online Article Text |
id | pubmed-4841412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48414122016-05-03 Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia Urban-Kowalczyk, Małgorzata Śmigielski, Janusz Strzelecki, Dominik Neuropsychiatr Dis Treat Original Research OBJECTIVES: Links between endorphins and dopaminergic transmission have not been fully explored in schizophrenia. Both endorphins excess and deficiency were postulated. CGRP is probably involved in dopaminergic transmission. The aim of this study was the evaluation of beta-endorphin (BE) and CGRP blood concentrations before and after treatment of severe schizophrenia. METHODS: Seventy patients treated with various antipsychotics, with severe symptoms of schizophrenia (51 with positive symptoms, 19 with negative symptoms), 15 first-degree relatives, and 44 healthy controls were included in the study. BE and CGRP blood concentrations were measured during patients severe schizophrenia and in their stable mental state after treatment. The results were compared with relatives and controls. RESULTS: BE and CGRP concentrations in patients with negative symptoms were higher than in relatives and in controls. BE levels in patients with positive symptoms were lower than in patients with negative symptoms (P<0.0000) and controls (P<0.0006). No significant changes in CGRP concentration were found in patient samples. CGRP levels in these samples were independent of treatment, but they were significantly higher than in relatives and controls. After the treatment, BE level decreased in patients with negative symptoms (P<0.0001) and increased in patients with positive symptoms (P<0.0000). No differences in BE concentration between patients in stable mental state, their relatives, and controls were found. CONCLUSION: Effective antipsychotic treatment results in “normalization” of BE level. Specific changes in BE concentration could be involved in dopaminergic transmission and related to some symptoms of schizophrenia. Dove Medical Press 2016-04-15 /pmc/articles/PMC4841412/ /pubmed/27143887 http://dx.doi.org/10.2147/NDT.S101647 Text en © 2016 Urban-Kowalczyk et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Urban-Kowalczyk, Małgorzata Śmigielski, Janusz Strzelecki, Dominik Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia |
title | Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia |
title_full | Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia |
title_fullStr | Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia |
title_full_unstemmed | Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia |
title_short | Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia |
title_sort | comparison of beta-endorphin and cgrp levels before and after treatment for severe schizophrenia |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841412/ https://www.ncbi.nlm.nih.gov/pubmed/27143887 http://dx.doi.org/10.2147/NDT.S101647 |
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