Cargando…

Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia

OBJECTIVES: Links between endorphins and dopaminergic transmission have not been fully explored in schizophrenia. Both endorphins excess and deficiency were postulated. CGRP is probably involved in dopaminergic transmission. The aim of this study was the evaluation of beta-endorphin (BE) and CGRP bl...

Descripción completa

Detalles Bibliográficos
Autores principales: Urban-Kowalczyk, Małgorzata, Śmigielski, Janusz, Strzelecki, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841412/
https://www.ncbi.nlm.nih.gov/pubmed/27143887
http://dx.doi.org/10.2147/NDT.S101647
_version_ 1782428389235228672
author Urban-Kowalczyk, Małgorzata
Śmigielski, Janusz
Strzelecki, Dominik
author_facet Urban-Kowalczyk, Małgorzata
Śmigielski, Janusz
Strzelecki, Dominik
author_sort Urban-Kowalczyk, Małgorzata
collection PubMed
description OBJECTIVES: Links between endorphins and dopaminergic transmission have not been fully explored in schizophrenia. Both endorphins excess and deficiency were postulated. CGRP is probably involved in dopaminergic transmission. The aim of this study was the evaluation of beta-endorphin (BE) and CGRP blood concentrations before and after treatment of severe schizophrenia. METHODS: Seventy patients treated with various antipsychotics, with severe symptoms of schizophrenia (51 with positive symptoms, 19 with negative symptoms), 15 first-degree relatives, and 44 healthy controls were included in the study. BE and CGRP blood concentrations were measured during patients severe schizophrenia and in their stable mental state after treatment. The results were compared with relatives and controls. RESULTS: BE and CGRP concentrations in patients with negative symptoms were higher than in relatives and in controls. BE levels in patients with positive symptoms were lower than in patients with negative symptoms (P<0.0000) and controls (P<0.0006). No significant changes in CGRP concentration were found in patient samples. CGRP levels in these samples were independent of treatment, but they were significantly higher than in relatives and controls. After the treatment, BE level decreased in patients with negative symptoms (P<0.0001) and increased in patients with positive symptoms (P<0.0000). No differences in BE concentration between patients in stable mental state, their relatives, and controls were found. CONCLUSION: Effective antipsychotic treatment results in “normalization” of BE level. Specific changes in BE concentration could be involved in dopaminergic transmission and related to some symptoms of schizophrenia.
format Online
Article
Text
id pubmed-4841412
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-48414122016-05-03 Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia Urban-Kowalczyk, Małgorzata Śmigielski, Janusz Strzelecki, Dominik Neuropsychiatr Dis Treat Original Research OBJECTIVES: Links between endorphins and dopaminergic transmission have not been fully explored in schizophrenia. Both endorphins excess and deficiency were postulated. CGRP is probably involved in dopaminergic transmission. The aim of this study was the evaluation of beta-endorphin (BE) and CGRP blood concentrations before and after treatment of severe schizophrenia. METHODS: Seventy patients treated with various antipsychotics, with severe symptoms of schizophrenia (51 with positive symptoms, 19 with negative symptoms), 15 first-degree relatives, and 44 healthy controls were included in the study. BE and CGRP blood concentrations were measured during patients severe schizophrenia and in their stable mental state after treatment. The results were compared with relatives and controls. RESULTS: BE and CGRP concentrations in patients with negative symptoms were higher than in relatives and in controls. BE levels in patients with positive symptoms were lower than in patients with negative symptoms (P<0.0000) and controls (P<0.0006). No significant changes in CGRP concentration were found in patient samples. CGRP levels in these samples were independent of treatment, but they were significantly higher than in relatives and controls. After the treatment, BE level decreased in patients with negative symptoms (P<0.0001) and increased in patients with positive symptoms (P<0.0000). No differences in BE concentration between patients in stable mental state, their relatives, and controls were found. CONCLUSION: Effective antipsychotic treatment results in “normalization” of BE level. Specific changes in BE concentration could be involved in dopaminergic transmission and related to some symptoms of schizophrenia. Dove Medical Press 2016-04-15 /pmc/articles/PMC4841412/ /pubmed/27143887 http://dx.doi.org/10.2147/NDT.S101647 Text en © 2016 Urban-Kowalczyk et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Urban-Kowalczyk, Małgorzata
Śmigielski, Janusz
Strzelecki, Dominik
Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia
title Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia
title_full Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia
title_fullStr Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia
title_full_unstemmed Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia
title_short Comparison of beta-endorphin and CGRP levels before and after treatment for severe schizophrenia
title_sort comparison of beta-endorphin and cgrp levels before and after treatment for severe schizophrenia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841412/
https://www.ncbi.nlm.nih.gov/pubmed/27143887
http://dx.doi.org/10.2147/NDT.S101647
work_keys_str_mv AT urbankowalczykmałgorzata comparisonofbetaendorphinandcgrplevelsbeforeandaftertreatmentforsevereschizophrenia
AT smigielskijanusz comparisonofbetaendorphinandcgrplevelsbeforeandaftertreatmentforsevereschizophrenia
AT strzeleckidominik comparisonofbetaendorphinandcgrplevelsbeforeandaftertreatmentforsevereschizophrenia