Autophagy inhibition enhances RAD001-induced cytotoxicity in human bladder cancer cells

BACKGROUND: Mammalian target of rapamycin (mTOR), involved in PI3K/AKT/mTOR pathway, is known to play a central role in regulating the growth of cancer cells. The PI3K/AKT/mTOR pathway enhances tumor survival and proliferation through suppressing autophagy, which sustains energy homeostasis by colle...

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Detalles Bibliográficos
Autores principales: Lin, Ji-Fan, Lin, Yi-Chia, Yang, Shan-Che, Tsai, Te-Fu, Chen, Hung-En, Chou, Kuang-Yu, Hwang, Thomas I-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841413/
https://www.ncbi.nlm.nih.gov/pubmed/27143856
http://dx.doi.org/10.2147/DDDT.S95900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841413/
https://www.ncbi.nlm.nih.gov/pubmed/27143856
http://dx.doi.org/10.2147/DDDT.S95900

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