Cargando…

Characteristics of Resting-State Functional Connectivity in HIV-Associated Neurocognitive Disorder

BACKGROUND: HIV-associated neurocognitive disorder (HAND) can occur in patients without prior AIDS defining illness and can be debilitating. This study aimed to evaluate the difference in the patterns of intrinsic brain activity between patients with or without HAND for deepening our understanding o...

Descripción completa

Detalles Bibliográficos
Autores principales: Ann, Hea Won, Jun, Suhnyoung, Shin, Na-Young, Han, Sanghoon, Ahn, Jin Young, Ahn, Mi Young, Jeon, Yong Duk, Jung, In Young, Kim, Moo Hyun, Jeong, Woo Yong, Ku, Nam Su, Kim, June Myung, Smith, Davey M., Choi, Jun Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841538/
https://www.ncbi.nlm.nih.gov/pubmed/27104345
http://dx.doi.org/10.1371/journal.pone.0153493
_version_ 1782428405170438144
author Ann, Hea Won
Jun, Suhnyoung
Shin, Na-Young
Han, Sanghoon
Ahn, Jin Young
Ahn, Mi Young
Jeon, Yong Duk
Jung, In Young
Kim, Moo Hyun
Jeong, Woo Yong
Ku, Nam Su
Kim, June Myung
Smith, Davey M.
Choi, Jun Yong
author_facet Ann, Hea Won
Jun, Suhnyoung
Shin, Na-Young
Han, Sanghoon
Ahn, Jin Young
Ahn, Mi Young
Jeon, Yong Duk
Jung, In Young
Kim, Moo Hyun
Jeong, Woo Yong
Ku, Nam Su
Kim, June Myung
Smith, Davey M.
Choi, Jun Yong
author_sort Ann, Hea Won
collection PubMed
description BACKGROUND: HIV-associated neurocognitive disorder (HAND) can occur in patients without prior AIDS defining illness and can be debilitating. This study aimed to evaluate the difference in the patterns of intrinsic brain activity between patients with or without HAND for deepening our understanding of HAND. METHODS: We evaluated 24 HIV-infected individuals, 12 with previously diagnosed HAND and 12 previously diagnosed without HAND, and 11 seronegative individuals. These individuals then underwent repeat NP testing and a functional brain MRI scan. For functional MRI analysis, seed-based analysis with bilateral precuneus cortex seed was applied. RESULTS: Among the 12 individuals with previously diagnosed HAND, 3 showed improvement of their neurocognitive function and 1 was excluded for worsening liver disease. Among the 12 patients who previously had normal neurocognitive function, 2 showed neurocognitive impairment. Overall, the HAND group, who had impaired cognitive function at the time of MRI scan, showed significant decrease of resting status functional connectivity between bilateral precuneus and prefrontal cortex (PFC) compared with nonHAND group, those who had normal neurocognitive function (Corrected P<0.05). The functional connectivity with the right inferior frontal operculum and right superior frontal gyrus was positively correlated with memory and learning ability. CONCLUSIONS: This cross-sectional study found a significant difference in fMRI patterns between patients with and without HAND. Decreased functional connectivity between precuneus and PFC could be possible functional substrate for cognitive dysfunction in HIV patients, which should be characterized in a longitudinal study.
format Online
Article
Text
id pubmed-4841538
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-48415382016-04-29 Characteristics of Resting-State Functional Connectivity in HIV-Associated Neurocognitive Disorder Ann, Hea Won Jun, Suhnyoung Shin, Na-Young Han, Sanghoon Ahn, Jin Young Ahn, Mi Young Jeon, Yong Duk Jung, In Young Kim, Moo Hyun Jeong, Woo Yong Ku, Nam Su Kim, June Myung Smith, Davey M. Choi, Jun Yong PLoS One Research Article BACKGROUND: HIV-associated neurocognitive disorder (HAND) can occur in patients without prior AIDS defining illness and can be debilitating. This study aimed to evaluate the difference in the patterns of intrinsic brain activity between patients with or without HAND for deepening our understanding of HAND. METHODS: We evaluated 24 HIV-infected individuals, 12 with previously diagnosed HAND and 12 previously diagnosed without HAND, and 11 seronegative individuals. These individuals then underwent repeat NP testing and a functional brain MRI scan. For functional MRI analysis, seed-based analysis with bilateral precuneus cortex seed was applied. RESULTS: Among the 12 individuals with previously diagnosed HAND, 3 showed improvement of their neurocognitive function and 1 was excluded for worsening liver disease. Among the 12 patients who previously had normal neurocognitive function, 2 showed neurocognitive impairment. Overall, the HAND group, who had impaired cognitive function at the time of MRI scan, showed significant decrease of resting status functional connectivity between bilateral precuneus and prefrontal cortex (PFC) compared with nonHAND group, those who had normal neurocognitive function (Corrected P<0.05). The functional connectivity with the right inferior frontal operculum and right superior frontal gyrus was positively correlated with memory and learning ability. CONCLUSIONS: This cross-sectional study found a significant difference in fMRI patterns between patients with and without HAND. Decreased functional connectivity between precuneus and PFC could be possible functional substrate for cognitive dysfunction in HIV patients, which should be characterized in a longitudinal study. Public Library of Science 2016-04-22 /pmc/articles/PMC4841538/ /pubmed/27104345 http://dx.doi.org/10.1371/journal.pone.0153493 Text en © 2016 Ann et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ann, Hea Won
Jun, Suhnyoung
Shin, Na-Young
Han, Sanghoon
Ahn, Jin Young
Ahn, Mi Young
Jeon, Yong Duk
Jung, In Young
Kim, Moo Hyun
Jeong, Woo Yong
Ku, Nam Su
Kim, June Myung
Smith, Davey M.
Choi, Jun Yong
Characteristics of Resting-State Functional Connectivity in HIV-Associated Neurocognitive Disorder
title Characteristics of Resting-State Functional Connectivity in HIV-Associated Neurocognitive Disorder
title_full Characteristics of Resting-State Functional Connectivity in HIV-Associated Neurocognitive Disorder
title_fullStr Characteristics of Resting-State Functional Connectivity in HIV-Associated Neurocognitive Disorder
title_full_unstemmed Characteristics of Resting-State Functional Connectivity in HIV-Associated Neurocognitive Disorder
title_short Characteristics of Resting-State Functional Connectivity in HIV-Associated Neurocognitive Disorder
title_sort characteristics of resting-state functional connectivity in hiv-associated neurocognitive disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841538/
https://www.ncbi.nlm.nih.gov/pubmed/27104345
http://dx.doi.org/10.1371/journal.pone.0153493
work_keys_str_mv AT annheawon characteristicsofrestingstatefunctionalconnectivityinhivassociatedneurocognitivedisorder
AT junsuhnyoung characteristicsofrestingstatefunctionalconnectivityinhivassociatedneurocognitivedisorder
AT shinnayoung characteristicsofrestingstatefunctionalconnectivityinhivassociatedneurocognitivedisorder
AT hansanghoon characteristicsofrestingstatefunctionalconnectivityinhivassociatedneurocognitivedisorder
AT ahnjinyoung characteristicsofrestingstatefunctionalconnectivityinhivassociatedneurocognitivedisorder
AT ahnmiyoung characteristicsofrestingstatefunctionalconnectivityinhivassociatedneurocognitivedisorder
AT jeonyongduk characteristicsofrestingstatefunctionalconnectivityinhivassociatedneurocognitivedisorder
AT junginyoung characteristicsofrestingstatefunctionalconnectivityinhivassociatedneurocognitivedisorder
AT kimmoohyun characteristicsofrestingstatefunctionalconnectivityinhivassociatedneurocognitivedisorder
AT jeongwooyong characteristicsofrestingstatefunctionalconnectivityinhivassociatedneurocognitivedisorder
AT kunamsu characteristicsofrestingstatefunctionalconnectivityinhivassociatedneurocognitivedisorder
AT kimjunemyung characteristicsofrestingstatefunctionalconnectivityinhivassociatedneurocognitivedisorder
AT smithdaveym characteristicsofrestingstatefunctionalconnectivityinhivassociatedneurocognitivedisorder
AT choijunyong characteristicsofrestingstatefunctionalconnectivityinhivassociatedneurocognitivedisorder