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Time-resolved multimodal analysis of Src Homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases

While the affinities and specificities of SH2 domain-phosphotyrosine interactions have been well characterized, spatio-temporal changes in phosphosite availability in response to signals, and their impact on recruitment of SH2-containing proteins in vivo, are not well understood. To address this iss...

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Detalles Bibliográficos
Autores principales:	Jadwin, Joshua A, Oh, Dongmyung, Curran, Timothy G, Ogiue-Ikeda, Mari, Jia, Lin, White, Forest M, Machida, Kazuya, Yu, Ji, Mayer, Bruce J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841779/ https://www.ncbi.nlm.nih.gov/pubmed/27071344 http://dx.doi.org/10.7554/eLife.11835

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