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MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial cancer
MicroRNAs (miRNAs) are a class of noncoding RNAs and function as key regulators of gene expression at the post-transcriptional level. In this study, we found that miR-495 reduces cell growth, induces apoptosis and suppresses the migration of endometrial cancer by directly inhibiting FOXC1 expression...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841847/ https://www.ncbi.nlm.nih.gov/pubmed/26198045 http://dx.doi.org/10.1007/s13277-015-3686-6 |
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author | Xu, Yan-Ying Tian, Jing Hao, Quan Yin, Li-Rong |
author_facet | Xu, Yan-Ying Tian, Jing Hao, Quan Yin, Li-Rong |
author_sort | Xu, Yan-Ying |
collection | PubMed |
description | MicroRNAs (miRNAs) are a class of noncoding RNAs and function as key regulators of gene expression at the post-transcriptional level. In this study, we found that miR-495 reduces cell growth, induces apoptosis and suppresses the migration of endometrial cancer by directly inhibiting FOXC1 expression. Further analysis revealed that FOXC1 promotes growth and migration and functions as an oncogene in vitro. FOXC1 overexpression reversed the cellular responses mediated by miR-495 in endometrial cancer cells. We also found that miR-495 suppresses the growth of endometrial cancer in vivo. Altogether, these results indicate that miR-495 acts as a tumour suppressor gene by targeting FOXC1 at the post-transcriptional level in endometrial cancer. |
format | Online Article Text |
id | pubmed-4841847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-48418472016-05-16 MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial cancer Xu, Yan-Ying Tian, Jing Hao, Quan Yin, Li-Rong Tumour Biol Research Article MicroRNAs (miRNAs) are a class of noncoding RNAs and function as key regulators of gene expression at the post-transcriptional level. In this study, we found that miR-495 reduces cell growth, induces apoptosis and suppresses the migration of endometrial cancer by directly inhibiting FOXC1 expression. Further analysis revealed that FOXC1 promotes growth and migration and functions as an oncogene in vitro. FOXC1 overexpression reversed the cellular responses mediated by miR-495 in endometrial cancer cells. We also found that miR-495 suppresses the growth of endometrial cancer in vivo. Altogether, these results indicate that miR-495 acts as a tumour suppressor gene by targeting FOXC1 at the post-transcriptional level in endometrial cancer. Springer Netherlands 2015-07-22 /pmc/articles/PMC4841847/ /pubmed/26198045 http://dx.doi.org/10.1007/s13277-015-3686-6 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Research Article Xu, Yan-Ying Tian, Jing Hao, Quan Yin, Li-Rong MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial cancer |
title | MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial cancer |
title_full | MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial cancer |
title_fullStr | MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial cancer |
title_full_unstemmed | MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial cancer |
title_short | MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial cancer |
title_sort | microrna-495 downregulates foxc1 expression to suppress cell growth and migration in endometrial cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841847/ https://www.ncbi.nlm.nih.gov/pubmed/26198045 http://dx.doi.org/10.1007/s13277-015-3686-6 |
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