Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients

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BACKGROUND: Serum levels of lipocalin 2 (LCN 2) and retinol-binding protein-4 (RBP 4), increase in type 2 diabetes mellitus (T2DM). We sought to determine whether serum LCN 2 and RBP 4 change after an intervention with omega-3 fatty acids supplementation in diabetic patients. METHODS: Forty-five typ...

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Detalles Bibliográficos
Autores principales: FARAHBAKHSH-FARSI, Payam, DJAZAYERY, Abolghassem, ESHRAGHIAN, Mohammad Reza, KOOHDANI, Fariba, ZAREI, Mahnaz, JAVANBAKHT, Mohammad Hassan, DERAKHSHANIAN, Hoda, DJALALI, Mahmoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841872/
https://www.ncbi.nlm.nih.gov/pubmed/27114982
Descripción
Sumario:BACKGROUND: Serum levels of lipocalin 2 (LCN 2) and retinol-binding protein-4 (RBP 4), increase in type 2 diabetes mellitus (T2DM). We sought to determine whether serum LCN 2 and RBP 4 change after an intervention with omega-3 fatty acids supplementation in diabetic patients. METHODS: Forty-five type 2 diabetic patients from Iranian Diabetic Association in Tehran, Iran in 2013 were randomly recruited into two groups: one group received 4 g/d omega-3 for 10 wk; and the control group received placebo. Blood samples, food intake records, anthropometric measurements were obtained from all participants at the beginning and end of the study. RESULTS: Fasting RBP 4 plasma levels significantly changed after 10 wk supplementation (P = 0.01). The LCN 2 concentrations decreased in omega-3 group, but the changes were not statistically significant. Omega-3 supplementation had no noticeable effect on anthropometric factors. CONCLUSION: These findings provide a rationale for omega-3 supplements aimed at lowering serum RBP 4 levels in T2DM.

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