Cargando…

Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review

Modulation of fat metabolism is an important component of the etiology of obesity as well as individual response to weight loss program. The influence of lipolysis process had receives many attentions in recent decades. Compared to that, fatty acid oxidation which occurred after lipolysis seems to b...

Descripción completa

Detalles Bibliográficos
Autor principal: Freitag Luglio, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Master Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841982/
https://www.ncbi.nlm.nih.gov/pubmed/27127449
_version_ 1782428456559050752
author Freitag Luglio, Harry
author_facet Freitag Luglio, Harry
author_sort Freitag Luglio, Harry
collection PubMed
description Modulation of fat metabolism is an important component of the etiology of obesity as well as individual response to weight loss program. The influence of lipolysis process had receives many attentions in recent decades. Compared to that, fatty acid oxidation which occurred after lipolysis seems to be less exposed. There are limited publications on how fatty acid oxidation influences predisposition to obesity, especially the importance of genetic variations of fatty acid oxidation proteins on development of obesity. The aim of this review is to provide recent knowledge on how polymorphism of genes related fatty acid oxidation is obtained. Studies in human as well as animal model showed that disturbance of genes related fatty acid oxidation process gave impact on body weight and risks to obesity. Several polymorphisms on CD36, CPT, ACS and FABP had been shown to be related to obesity either by regulating enzymatic activity or directly influence fatty acid oxidation process.
format Online
Article
Text
id pubmed-4841982
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Master Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-48419822016-04-28 Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review Freitag Luglio, Harry Int J Biomed Sci Review Article Modulation of fat metabolism is an important component of the etiology of obesity as well as individual response to weight loss program. The influence of lipolysis process had receives many attentions in recent decades. Compared to that, fatty acid oxidation which occurred after lipolysis seems to be less exposed. There are limited publications on how fatty acid oxidation influences predisposition to obesity, especially the importance of genetic variations of fatty acid oxidation proteins on development of obesity. The aim of this review is to provide recent knowledge on how polymorphism of genes related fatty acid oxidation is obtained. Studies in human as well as animal model showed that disturbance of genes related fatty acid oxidation process gave impact on body weight and risks to obesity. Several polymorphisms on CD36, CPT, ACS and FABP had been shown to be related to obesity either by regulating enzymatic activity or directly influence fatty acid oxidation process. Master Publishing Group 2016-03 /pmc/articles/PMC4841982/ /pubmed/27127449 Text en © Harry Freitag Luglio. Licensee Master Publishing Group http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review Article
Freitag Luglio, Harry
Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review
title Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review
title_full Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review
title_fullStr Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review
title_full_unstemmed Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review
title_short Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review
title_sort genetic variation of fatty acid oxidation and obesity, a literature review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841982/
https://www.ncbi.nlm.nih.gov/pubmed/27127449
work_keys_str_mv AT freitagluglioharry geneticvariationoffattyacidoxidationandobesityaliteraturereview