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Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review
Modulation of fat metabolism is an important component of the etiology of obesity as well as individual response to weight loss program. The influence of lipolysis process had receives many attentions in recent decades. Compared to that, fatty acid oxidation which occurred after lipolysis seems to b...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Master Publishing Group
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841982/ https://www.ncbi.nlm.nih.gov/pubmed/27127449 |
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author | Freitag Luglio, Harry |
author_facet | Freitag Luglio, Harry |
author_sort | Freitag Luglio, Harry |
collection | PubMed |
description | Modulation of fat metabolism is an important component of the etiology of obesity as well as individual response to weight loss program. The influence of lipolysis process had receives many attentions in recent decades. Compared to that, fatty acid oxidation which occurred after lipolysis seems to be less exposed. There are limited publications on how fatty acid oxidation influences predisposition to obesity, especially the importance of genetic variations of fatty acid oxidation proteins on development of obesity. The aim of this review is to provide recent knowledge on how polymorphism of genes related fatty acid oxidation is obtained. Studies in human as well as animal model showed that disturbance of genes related fatty acid oxidation process gave impact on body weight and risks to obesity. Several polymorphisms on CD36, CPT, ACS and FABP had been shown to be related to obesity either by regulating enzymatic activity or directly influence fatty acid oxidation process. |
format | Online Article Text |
id | pubmed-4841982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Master Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48419822016-04-28 Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review Freitag Luglio, Harry Int J Biomed Sci Review Article Modulation of fat metabolism is an important component of the etiology of obesity as well as individual response to weight loss program. The influence of lipolysis process had receives many attentions in recent decades. Compared to that, fatty acid oxidation which occurred after lipolysis seems to be less exposed. There are limited publications on how fatty acid oxidation influences predisposition to obesity, especially the importance of genetic variations of fatty acid oxidation proteins on development of obesity. The aim of this review is to provide recent knowledge on how polymorphism of genes related fatty acid oxidation is obtained. Studies in human as well as animal model showed that disturbance of genes related fatty acid oxidation process gave impact on body weight and risks to obesity. Several polymorphisms on CD36, CPT, ACS and FABP had been shown to be related to obesity either by regulating enzymatic activity or directly influence fatty acid oxidation process. Master Publishing Group 2016-03 /pmc/articles/PMC4841982/ /pubmed/27127449 Text en © Harry Freitag Luglio. Licensee Master Publishing Group http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Article Freitag Luglio, Harry Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review |
title | Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review |
title_full | Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review |
title_fullStr | Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review |
title_full_unstemmed | Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review |
title_short | Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review |
title_sort | genetic variation of fatty acid oxidation and obesity, a literature review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841982/ https://www.ncbi.nlm.nih.gov/pubmed/27127449 |
work_keys_str_mv | AT freitagluglioharry geneticvariationoffattyacidoxidationandobesityaliteraturereview |