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No Significant Reduction of Circulating Endothelial-Derived and Platelet-Derived Microparticles in Patients with Psoriasis Successfully Treated with Anti-IL12/23

Psoriasis is associated with atherosclerosis, in which circulating microparticles play an important role. In severe psoriasis, there was an increase of endothelial- and platelet- microparticles which could be decreased by anti-TNFα. However, whether anti-IL-12/23 treatment would decrease the level o...

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Detalles Bibliográficos
Autores principales: Ho, Ji-Chen, Lee, Chih-Hung, Lin, Shang-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842038/
https://www.ncbi.nlm.nih.gov/pubmed/27144162
http://dx.doi.org/10.1155/2016/3242143
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author Ho, Ji-Chen
Lee, Chih-Hung
Lin, Shang-Hung
author_facet Ho, Ji-Chen
Lee, Chih-Hung
Lin, Shang-Hung
author_sort Ho, Ji-Chen
collection PubMed
description Psoriasis is associated with atherosclerosis, in which circulating microparticles play an important role. In severe psoriasis, there was an increase of endothelial- and platelet- microparticles which could be decreased by anti-TNFα. However, whether anti-IL-12/23 treatment would decrease the level of microparticles remains unknown. Our study showed that, despite the clinical improvement of psoriasis after IL-12/13 blockage, the increased levels of circulating CD41a and CD31 microparticles were unchanged after anti-IL-12/23. This result suggested that anti-IL12/23 treatment may not alter the development of cardiovascular disease in patients with psoriasis.
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spelling pubmed-48420382016-05-03 No Significant Reduction of Circulating Endothelial-Derived and Platelet-Derived Microparticles in Patients with Psoriasis Successfully Treated with Anti-IL12/23 Ho, Ji-Chen Lee, Chih-Hung Lin, Shang-Hung Biomed Res Int Clinical Study Psoriasis is associated with atherosclerosis, in which circulating microparticles play an important role. In severe psoriasis, there was an increase of endothelial- and platelet- microparticles which could be decreased by anti-TNFα. However, whether anti-IL-12/23 treatment would decrease the level of microparticles remains unknown. Our study showed that, despite the clinical improvement of psoriasis after IL-12/13 blockage, the increased levels of circulating CD41a and CD31 microparticles were unchanged after anti-IL-12/23. This result suggested that anti-IL12/23 treatment may not alter the development of cardiovascular disease in patients with psoriasis. Hindawi Publishing Corporation 2016 2016-04-10 /pmc/articles/PMC4842038/ /pubmed/27144162 http://dx.doi.org/10.1155/2016/3242143 Text en Copyright © 2016 Ji-Chen Ho et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Ho, Ji-Chen
Lee, Chih-Hung
Lin, Shang-Hung
No Significant Reduction of Circulating Endothelial-Derived and Platelet-Derived Microparticles in Patients with Psoriasis Successfully Treated with Anti-IL12/23
title No Significant Reduction of Circulating Endothelial-Derived and Platelet-Derived Microparticles in Patients with Psoriasis Successfully Treated with Anti-IL12/23
title_full No Significant Reduction of Circulating Endothelial-Derived and Platelet-Derived Microparticles in Patients with Psoriasis Successfully Treated with Anti-IL12/23
title_fullStr No Significant Reduction of Circulating Endothelial-Derived and Platelet-Derived Microparticles in Patients with Psoriasis Successfully Treated with Anti-IL12/23
title_full_unstemmed No Significant Reduction of Circulating Endothelial-Derived and Platelet-Derived Microparticles in Patients with Psoriasis Successfully Treated with Anti-IL12/23
title_short No Significant Reduction of Circulating Endothelial-Derived and Platelet-Derived Microparticles in Patients with Psoriasis Successfully Treated with Anti-IL12/23
title_sort no significant reduction of circulating endothelial-derived and platelet-derived microparticles in patients with psoriasis successfully treated with anti-il12/23
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842038/
https://www.ncbi.nlm.nih.gov/pubmed/27144162
http://dx.doi.org/10.1155/2016/3242143
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