Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages

BACKGROUND: Particulate matter has been shown to stimulate the innate immune system and induce acute inflammation. Therefore, while nanotechnology has the potential to provide therapeutic formulations with improved efficacy, there are concerns such pharmaceutical preparations could induce unwanted i...

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Detalles Bibliográficos
Autores principales: Hughes, Caroline S., Colhoun, Liza M., Bains, Baljinder K., Kilgour, Joanne D., Burden, Roberta E., Burrows, James F., Lavelle, Ed C., Gilmore, Brendan F., Scott, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842290/
https://www.ncbi.nlm.nih.gov/pubmed/27108091
http://dx.doi.org/10.1186/s12989-016-0129-5

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