AB181. Analysis of clinical and pathological features of mixed epithelial and stromal tumor of the kidney

OBJECTIVE: To study the histology and pathology clinical features, diagnosis, identification and treatment of mixed epithelial and stromal tumor of the kidney (MESTK). METHODS: One case of MESTK was reported. One patient’s clinical data with mixed epithelial and stromal tumor of the kidney in our department was reported. Male, 53 years old, physical examination found the left kidney cyst. B-ultrasonic, ultrasonic imaging and CT of the left kidney and upper lateral visible cysts, size 7.5×6.4×6.4 cm, and the adjacent in the renal sinus cyst space form, can be seen in the space limitations, involving the scope of 6.5×2.8×2.8 cm. Retrieve PubMed and domestic literature of CNKI database, reported a total of 160 cases, including malignant change in 12 cases of foreign literature, and their clinical data were reviewed. RESULTS: Patient with surgical treatment had complete resection of the tumor and ipsilateral kidney. The tumor consisted of multiple cystic and solid areas on gross examination, and intracapsular surface coating flat, cubic, hobnail and stratified epithelium, partial epithelial hyperplasia, have formed at the regional and ventricular papillary structures. Local tissue is at early invasive. Immunohistochemistry: Vimentin (+), CK7 (+), Pax8 (−), SAM partial (+), P504s weak (+), TFE3 partial (+), ER (−), PR (+), Ki67 <1% positive tumor cells. There was no evidence of recurrence and metastasis during the follow-up of 6 months. CONCLUSIONS: MESTK on domestic and foreign clinical is rare, and has non-specific clinical manifestations. Additionally, surgery is the main therapy for MESTK and there is the possibility of malignant and malignant lesions has no effective treatment.