AB185. Clinical and pathological features of sarcomatoid carcinoma of the renal pelvis and literature review

OBJECTIVE: To explore the clinical, pathology, and prognosis of sarcomatoid carcinoma of the renal pelvis. METHODS: A case of the diagnosis and treatment of sarcomatoid carcinoma of the renal pelvis in our hospital were retrospectively analyzed. Articles were searched from the full-text databases, such as NCBI and PUBMED, the dates of clinical and pathology was collected from the satisfied articles, the feature of clinical, pathology and prognosis were summarized. RESULTS: Thirty-nine articles were screened, after screening, only 15 articles met the inclusion criteria, total 32 cases were included, combined with our center, 33 cases were included in the final analyzed. Most patients with sarcomatoid carcinoma of the renal pelvis are diagnosed because of abdominal pain and hematuria, most of them pathology ≥T2, according to the TNM classification system, most of the patients have radical prostatectomy. According to univariable Cox model, Not yet considered whether the impact of the prognosis of patients with follow-up treatment of the patients, 6 cases were recurrence, The median time to recurrence was three months, a total of 13 patients died, with a median time to death was seven months. Univariate analysis showed that patients’ gender, age, region, metastasis, tumor size, pathological stage has no effect on the prognosis of patients. CONCLUSIONS: Most likely resulting from the advanced stage of the disease at diagnosis and a poor response to systemic therapy. The present analysis suggests a poor prognosis for the majority of sarcomatoid carcinoma of the renal pelvis patients. To improve the survival rate of RPSC, it is therefore essential to perform an early diagnosis and early radical surgery.