AB177. Clinical and pathological research of prostate cancer with Gleason score 10

OBJECTIVE: Prostate cancer is the second common malignancies of men around the world. According to the database about prostate cancer of our institute, in our study, we will analyses prostate cancer patients with Gleason score 10 and investigate its clinical and pathological features. METHODS: We retrospectively review 30 prostate cancer patients with complete clinical information in our hospital between July 2010 and July 2013. RESULTS: The pathology of tissue specimens is that all of them are Gleason score 10. ECT shows that 10 with bone metastasis, 1 with lung metastasis. Mean value of total serum PSA is 56.35 ng/mL and average PSAD is 0.57. Mean BMI is 23.90, but there are 14 patients with a BMI more than 25 accounting for 47% of the total. CONCLUSIONS: By our initial research, we find that prostate cancer with Gleason 10 is the highest grade pathological malignancy tumor. It is usually found in elder men, especially more than 70 years old. Patients always have higher BMI and bigger total PSA and PSAD. Patients frequently have metastatic sites with seminal vesicles, bone and other places, however, it does not has a higher risk of metastasis. Therefore, we can see prostate cancers with Gleason 10 as special style to treat.