Cargando…
AB130. The expression and clinical significance of HIF-1α in bladder urothelial carcinoma
OBJECTIVE: To observe the expression of hypoxia inducible factor-1α (HIF-1α) in bladder urothelial carcinoma (BUC) and the relationship between it with the metastasis of BUC. METHODS: Expression of HIF-1α was detected by SP immunohistochemistry in BUC, to find the relationship of HIF-1α with the cli...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842543/ http://dx.doi.org/10.21037/tau.2016.s130 |
_version_ | 1782428539088273408 |
---|---|
author | Fan, Haitao |
author_facet | Fan, Haitao |
author_sort | Fan, Haitao |
collection | PubMed |
description | OBJECTIVE: To observe the expression of hypoxia inducible factor-1α (HIF-1α) in bladder urothelial carcinoma (BUC) and the relationship between it with the metastasis of BUC. METHODS: Expression of HIF-1α was detected by SP immunohistochemistry in BUC, to find the relationship of HIF-1α with the clinical pathological characteristics and lymph node metastasis of BUC patients RESULTS: The positive expression rate of HIF-1α was 75.6% in 90 cases with BUC (68/90), the positive expression rate in 30 cases of normal bladder tissue cells is 6.7% (2/30), compare the two groups, there was a significant difference between their expression (P<0.01). In different pathological grading and clinical staging, and also in lymph node metastasis, its expressive discrepancy was statistically significant (P<0.05) CONCLUSIONS: The HIF-1 α protein of BUC patients with abnormal high expression is closely related to the cancer growth, suggesting that the protein can be used as an important molecular biological behavior and prognosis judgement of BUC cell markers, also has some clinical reference value in the treatment of postoperative follow-up guidance. |
format | Online Article Text |
id | pubmed-4842543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-48425432016-05-09 AB130. The expression and clinical significance of HIF-1α in bladder urothelial carcinoma Fan, Haitao Transl Androl Urol Printed Abstracts OBJECTIVE: To observe the expression of hypoxia inducible factor-1α (HIF-1α) in bladder urothelial carcinoma (BUC) and the relationship between it with the metastasis of BUC. METHODS: Expression of HIF-1α was detected by SP immunohistochemistry in BUC, to find the relationship of HIF-1α with the clinical pathological characteristics and lymph node metastasis of BUC patients RESULTS: The positive expression rate of HIF-1α was 75.6% in 90 cases with BUC (68/90), the positive expression rate in 30 cases of normal bladder tissue cells is 6.7% (2/30), compare the two groups, there was a significant difference between their expression (P<0.01). In different pathological grading and clinical staging, and also in lymph node metastasis, its expressive discrepancy was statistically significant (P<0.05) CONCLUSIONS: The HIF-1 α protein of BUC patients with abnormal high expression is closely related to the cancer growth, suggesting that the protein can be used as an important molecular biological behavior and prognosis judgement of BUC cell markers, also has some clinical reference value in the treatment of postoperative follow-up guidance. AME Publishing Company 2016-04 /pmc/articles/PMC4842543/ http://dx.doi.org/10.21037/tau.2016.s130 Text en 2016 Translational Andrology and Urology. All rights reserved. |
spellingShingle | Printed Abstracts Fan, Haitao AB130. The expression and clinical significance of HIF-1α in bladder urothelial carcinoma |
title | AB130. The expression and clinical significance of HIF-1α in bladder urothelial carcinoma |
title_full | AB130. The expression and clinical significance of HIF-1α in bladder urothelial carcinoma |
title_fullStr | AB130. The expression and clinical significance of HIF-1α in bladder urothelial carcinoma |
title_full_unstemmed | AB130. The expression and clinical significance of HIF-1α in bladder urothelial carcinoma |
title_short | AB130. The expression and clinical significance of HIF-1α in bladder urothelial carcinoma |
title_sort | ab130. the expression and clinical significance of hif-1α in bladder urothelial carcinoma |
topic | Printed Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842543/ http://dx.doi.org/10.21037/tau.2016.s130 |
work_keys_str_mv | AT fanhaitao ab130theexpressionandclinicalsignificanceofhif1ainbladderurothelialcarcinoma |