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AB130. The expression and clinical significance of HIF-1α in bladder urothelial carcinoma

OBJECTIVE: To observe the expression of hypoxia inducible factor-1α (HIF-1α) in bladder urothelial carcinoma (BUC) and the relationship between it with the metastasis of BUC. METHODS: Expression of HIF-1α was detected by SP immunohistochemistry in BUC, to find the relationship of HIF-1α with the cli...

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Detalles Bibliográficos
Autor principal: Fan, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842543/
http://dx.doi.org/10.21037/tau.2016.s130
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author Fan, Haitao
author_facet Fan, Haitao
author_sort Fan, Haitao
collection PubMed
description OBJECTIVE: To observe the expression of hypoxia inducible factor-1α (HIF-1α) in bladder urothelial carcinoma (BUC) and the relationship between it with the metastasis of BUC. METHODS: Expression of HIF-1α was detected by SP immunohistochemistry in BUC, to find the relationship of HIF-1α with the clinical pathological characteristics and lymph node metastasis of BUC patients RESULTS: The positive expression rate of HIF-1α was 75.6% in 90 cases with BUC (68/90), the positive expression rate in 30 cases of normal bladder tissue cells is 6.7% (2/30), compare the two groups, there was a significant difference between their expression (P<0.01). In different pathological grading and clinical staging, and also in lymph node metastasis, its expressive discrepancy was statistically significant (P<0.05) CONCLUSIONS: The HIF-1 α protein of BUC patients with abnormal high expression is closely related to the cancer growth, suggesting that the protein can be used as an important molecular biological behavior and prognosis judgement of BUC cell markers, also has some clinical reference value in the treatment of postoperative follow-up guidance.
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spelling pubmed-48425432016-05-09 AB130. The expression and clinical significance of HIF-1α in bladder urothelial carcinoma Fan, Haitao Transl Androl Urol Printed Abstracts OBJECTIVE: To observe the expression of hypoxia inducible factor-1α (HIF-1α) in bladder urothelial carcinoma (BUC) and the relationship between it with the metastasis of BUC. METHODS: Expression of HIF-1α was detected by SP immunohistochemistry in BUC, to find the relationship of HIF-1α with the clinical pathological characteristics and lymph node metastasis of BUC patients RESULTS: The positive expression rate of HIF-1α was 75.6% in 90 cases with BUC (68/90), the positive expression rate in 30 cases of normal bladder tissue cells is 6.7% (2/30), compare the two groups, there was a significant difference between their expression (P<0.01). In different pathological grading and clinical staging, and also in lymph node metastasis, its expressive discrepancy was statistically significant (P<0.05) CONCLUSIONS: The HIF-1 α protein of BUC patients with abnormal high expression is closely related to the cancer growth, suggesting that the protein can be used as an important molecular biological behavior and prognosis judgement of BUC cell markers, also has some clinical reference value in the treatment of postoperative follow-up guidance. AME Publishing Company 2016-04 /pmc/articles/PMC4842543/ http://dx.doi.org/10.21037/tau.2016.s130 Text en 2016 Translational Andrology and Urology. All rights reserved.
spellingShingle Printed Abstracts
Fan, Haitao
AB130. The expression and clinical significance of HIF-1α in bladder urothelial carcinoma
title AB130. The expression and clinical significance of HIF-1α in bladder urothelial carcinoma
title_full AB130. The expression and clinical significance of HIF-1α in bladder urothelial carcinoma
title_fullStr AB130. The expression and clinical significance of HIF-1α in bladder urothelial carcinoma
title_full_unstemmed AB130. The expression and clinical significance of HIF-1α in bladder urothelial carcinoma
title_short AB130. The expression and clinical significance of HIF-1α in bladder urothelial carcinoma
title_sort ab130. the expression and clinical significance of hif-1α in bladder urothelial carcinoma
topic Printed Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842543/
http://dx.doi.org/10.21037/tau.2016.s130
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