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AB246. Effect of hypoxia inducible factor mediated EMT in the mechanism of detrusor instability

BACKGROUND: To detect the effect of hypoxia inducible factor mediated EMT in the mechanism of detrusor instability. METHODS: A total of 49 patients with detrusor instability (DI) secondary to bladder outlet obstruction (BOO) were randomly chosen according to the urodynamic result as the study group....

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Detalles Bibliográficos
Autores principales: Wei, Wei, Yang, Jinyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842629/
http://dx.doi.org/10.21037/tau.2016.s246
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author Wei, Wei
Yang, Jinyi
author_facet Wei, Wei
Yang, Jinyi
author_sort Wei, Wei
collection PubMed
description BACKGROUND: To detect the effect of hypoxia inducible factor mediated EMT in the mechanism of detrusor instability. METHODS: A total of 49 patients with detrusor instability (DI) secondary to bladder outlet obstruction (BOO) were randomly chosen according to the urodynamic result as the study group. 36 patients with BOO proved with detrusor instability (DS) by urodynamic as control group. The detrusor specimens were obtained in operation. The expression of E-cadherin, detrusor collagen content and HIF were determined in the detrusor muscle of two groups respectively. Statistical analysis was carried out on the measured results by compute. Changes of E-cadherin, collagen content and HIF were compared. RESULTS: The expression of E-cadherin was in the DI group was significantly lower than the DS group, collagen and HIF were significantly increased than the DS group (P<0.05). CONCLUSIONS: The histology and molecular biology were changed caused by the BOO, may through mediated the EMT, inhibited the activity of calcium mucin, lead to E-cadherin as the main constituent of intercellular adhesion failure, and then epithelial cells transferred into mesenchymal cells. Therefore we suggest that the interaction between them may represent a novel therapeutic target for the development of novel target based therapies of DI.
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spelling pubmed-48426292016-05-09 AB246. Effect of hypoxia inducible factor mediated EMT in the mechanism of detrusor instability Wei, Wei Yang, Jinyi Transl Androl Urol Printed Abstracts BACKGROUND: To detect the effect of hypoxia inducible factor mediated EMT in the mechanism of detrusor instability. METHODS: A total of 49 patients with detrusor instability (DI) secondary to bladder outlet obstruction (BOO) were randomly chosen according to the urodynamic result as the study group. 36 patients with BOO proved with detrusor instability (DS) by urodynamic as control group. The detrusor specimens were obtained in operation. The expression of E-cadherin, detrusor collagen content and HIF were determined in the detrusor muscle of two groups respectively. Statistical analysis was carried out on the measured results by compute. Changes of E-cadherin, collagen content and HIF were compared. RESULTS: The expression of E-cadherin was in the DI group was significantly lower than the DS group, collagen and HIF were significantly increased than the DS group (P<0.05). CONCLUSIONS: The histology and molecular biology were changed caused by the BOO, may through mediated the EMT, inhibited the activity of calcium mucin, lead to E-cadherin as the main constituent of intercellular adhesion failure, and then epithelial cells transferred into mesenchymal cells. Therefore we suggest that the interaction between them may represent a novel therapeutic target for the development of novel target based therapies of DI. AME Publishing Company 2016-04 /pmc/articles/PMC4842629/ http://dx.doi.org/10.21037/tau.2016.s246 Text en 2016 Translational Andrology and Urology. All rights reserved.
spellingShingle Printed Abstracts
Wei, Wei
Yang, Jinyi
AB246. Effect of hypoxia inducible factor mediated EMT in the mechanism of detrusor instability
title AB246. Effect of hypoxia inducible factor mediated EMT in the mechanism of detrusor instability
title_full AB246. Effect of hypoxia inducible factor mediated EMT in the mechanism of detrusor instability
title_fullStr AB246. Effect of hypoxia inducible factor mediated EMT in the mechanism of detrusor instability
title_full_unstemmed AB246. Effect of hypoxia inducible factor mediated EMT in the mechanism of detrusor instability
title_short AB246. Effect of hypoxia inducible factor mediated EMT in the mechanism of detrusor instability
title_sort ab246. effect of hypoxia inducible factor mediated emt in the mechanism of detrusor instability
topic Printed Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842629/
http://dx.doi.org/10.21037/tau.2016.s246
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