AB009. Prognostic outcomes and risk factors for patients with renal cell carcinoma and venous tumor thrombus after radical nephrectomy and thrombectomy: the prognostic significance of venous tumor thrombus level

BACKGROUND: To evaluate the prognostic outcomes and risk factors for renal cell carcinoma (RCC) patients with venous tumor thrombus in China. METHODS: We reviewed the clinical information of 256 patients who underwent radical nephrectomy and thrombectomy. Overall and cancer-specific survival rates were analyzed. Univariate and multivariate analyses were used to investigate the potential prognostic factors. RESULTS: The median survival time was 45 months. The 5-year overall survival and cancer-specific survival rate were 44.2% and 47.2% for all patients. No matter for all patients or N0M0 patients, significant survival difference were observed between four different tumor thrombus levels, and between early (below hepatic vein) and advanced (above hepatic vein) tumor thrombus. Multivariate analysis demonstrated that higher tumor thrombus level (P=0.016, RR =1.58), N (P=0.013, RR =2.60), M (P<0.001, RR =4.14) stages and adrenal gland invasion (P=0.001, RR =4.91) were the most significant negative prognostic predictors. CONCLUSIONS: In this study, we reported the most cases of RCC patients with venous extension in China. We proved that patients with RCC and venous tumor thrombus may have relative promising long-term survival rate, especially for those with early tumor thrombus.