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AB188. Vasohibin-1 and microvessel density predict prognosis in clear cell renal cell carcinoma
OBJECTIVE: To investigate the expression of vasohibin-1(VASH-1) and microvessel density (MVD) marked with CD34 in clear cell renal cell carcinoma (ccRCC) and analyze their correlations with prognosis. METHODS: From January 2006 to December 2008, the clinical and pathologic data of 79 patients with c...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842732/ http://dx.doi.org/10.21037/tau.2016.s188 |
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author | Tian, Hao Zhu, Shimiao Li, Xing Wen, Simeng Shang, Zhiqun Niu, Yuanjie |
author_facet | Tian, Hao Zhu, Shimiao Li, Xing Wen, Simeng Shang, Zhiqun Niu, Yuanjie |
author_sort | Tian, Hao |
collection | PubMed |
description | OBJECTIVE: To investigate the expression of vasohibin-1(VASH-1) and microvessel density (MVD) marked with CD34 in clear cell renal cell carcinoma (ccRCC) and analyze their correlations with prognosis. METHODS: From January 2006 to December 2008, the clinical and pathologic data of 79 patients with ccRCC were retrospectively analyzed. Expressions of VASH-1 and CD34 in their tissue samples were detected by immunohistochemical (IHC) staining. For VASH-1 assessment, the staining intensity of positive tumor cells were evaluated semi-quantitatively and measured by Average Optical Density (AOD) for further analysis. The microvessel density (MVD) was counted using Weidner’s method. Statistical analysis was performed using SPSS 19.0. RESULTS: The AOD of VASH1 in the 79 cancer tissues was 0.0435±0.0178. The MVD value marked by CD34 in the 79 cancer tissues was (55±34) profiles/HPF. The expression of MVD and VASH1 significantly varied with tumor stages and necrosis presence (P<0.05). Assessed by Spearman’s correlation, the expression of VASH1 was negatively associated with MVD (r=−0.641, P<0.05). The overall survival (OS) and recurrence-free survival (RFS) in ccRCC patients with high VASH1 expression were significantly worse than those low VASH1 expression (P<0.05).The multivariate analysis showed that age, tumor stage and necrosis presence were significantly correlated to OS and RFS in ccRCC patients. CONCLUSIONS: VASH1 is potentially valuable in prognostic evaluation of ccRCC. |
format | Online Article Text |
id | pubmed-4842732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-48427322016-05-09 AB188. Vasohibin-1 and microvessel density predict prognosis in clear cell renal cell carcinoma Tian, Hao Zhu, Shimiao Li, Xing Wen, Simeng Shang, Zhiqun Niu, Yuanjie Transl Androl Urol Printed Abstracts OBJECTIVE: To investigate the expression of vasohibin-1(VASH-1) and microvessel density (MVD) marked with CD34 in clear cell renal cell carcinoma (ccRCC) and analyze their correlations with prognosis. METHODS: From January 2006 to December 2008, the clinical and pathologic data of 79 patients with ccRCC were retrospectively analyzed. Expressions of VASH-1 and CD34 in their tissue samples were detected by immunohistochemical (IHC) staining. For VASH-1 assessment, the staining intensity of positive tumor cells were evaluated semi-quantitatively and measured by Average Optical Density (AOD) for further analysis. The microvessel density (MVD) was counted using Weidner’s method. Statistical analysis was performed using SPSS 19.0. RESULTS: The AOD of VASH1 in the 79 cancer tissues was 0.0435±0.0178. The MVD value marked by CD34 in the 79 cancer tissues was (55±34) profiles/HPF. The expression of MVD and VASH1 significantly varied with tumor stages and necrosis presence (P<0.05). Assessed by Spearman’s correlation, the expression of VASH1 was negatively associated with MVD (r=−0.641, P<0.05). The overall survival (OS) and recurrence-free survival (RFS) in ccRCC patients with high VASH1 expression were significantly worse than those low VASH1 expression (P<0.05).The multivariate analysis showed that age, tumor stage and necrosis presence were significantly correlated to OS and RFS in ccRCC patients. CONCLUSIONS: VASH1 is potentially valuable in prognostic evaluation of ccRCC. AME Publishing Company 2016-04 /pmc/articles/PMC4842732/ http://dx.doi.org/10.21037/tau.2016.s188 Text en 2016 Translational Andrology and Urology. All rights reserved. |
spellingShingle | Printed Abstracts Tian, Hao Zhu, Shimiao Li, Xing Wen, Simeng Shang, Zhiqun Niu, Yuanjie AB188. Vasohibin-1 and microvessel density predict prognosis in clear cell renal cell carcinoma |
title | AB188. Vasohibin-1 and microvessel density predict prognosis in clear cell renal cell carcinoma |
title_full | AB188. Vasohibin-1 and microvessel density predict prognosis in clear cell renal cell carcinoma |
title_fullStr | AB188. Vasohibin-1 and microvessel density predict prognosis in clear cell renal cell carcinoma |
title_full_unstemmed | AB188. Vasohibin-1 and microvessel density predict prognosis in clear cell renal cell carcinoma |
title_short | AB188. Vasohibin-1 and microvessel density predict prognosis in clear cell renal cell carcinoma |
title_sort | ab188. vasohibin-1 and microvessel density predict prognosis in clear cell renal cell carcinoma |
topic | Printed Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842732/ http://dx.doi.org/10.21037/tau.2016.s188 |
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