Bioactivity Focus of α-Cyano-4-hydroxycinnamic acid (CHCA) Leads to Effective Multifunctional Aldose Reductase Inhibitors

Bioactivity focus on α-cyano-4-hydroxycinnamic acid (CHCA) scaffold results in a small library of novel multifunctional aldose reductase (ALR2) inhibitors. All the entities displayed good to excellent inhibition with IC(50) 72–405 nM. (R,E)-N-(3-(2-acetamido-3-(benzyloxy)propanamido)propyl)-2-cyano-...

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Detalles Bibliográficos
Autores principales: Zhang, Laitao, Li, Yi-Fang, Yuan, Sheng, Zhang, Shijie, Zheng, Huanhuan, Liu, Jie, Sun, Pinghua, Gu, Yijun, Kurihara, Hiroshi, He, Rong-Rong, Chen, Heru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842970/
https://www.ncbi.nlm.nih.gov/pubmed/27109517
http://dx.doi.org/10.1038/srep24942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842970/
https://www.ncbi.nlm.nih.gov/pubmed/27109517
http://dx.doi.org/10.1038/srep24942

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