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Bioactivity Focus of α-Cyano-4-hydroxycinnamic acid (CHCA) Leads to Effective Multifunctional Aldose Reductase Inhibitors
Bioactivity focus on α-cyano-4-hydroxycinnamic acid (CHCA) scaffold results in a small library of novel multifunctional aldose reductase (ALR2) inhibitors. All the entities displayed good to excellent inhibition with IC(50) 72–405 nM. (R,E)-N-(3-(2-acetamido-3-(benzyloxy)propanamido)propyl)-2-cyano-...
Autores principales: | Zhang, Laitao, Li, Yi-Fang, Yuan, Sheng, Zhang, Shijie, Zheng, Huanhuan, Liu, Jie, Sun, Pinghua, Gu, Yijun, Kurihara, Hiroshi, He, Rong-Rong, Chen, Heru |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842970/ https://www.ncbi.nlm.nih.gov/pubmed/27109517 http://dx.doi.org/10.1038/srep24942 |
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