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Structures of Two Distinct Conformations of holo-Nonribosomal Peptide Synthetases

Many important natural products are produced by multidomain nonribosomal peptide synthetases (NRPSs)(1–4). During synthesis, intermediates are covalently bound to integrated carrier domains and transported to neighboring catalytic domains in an assembly line fashion(5). Understanding the structural...

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Detalles Bibliográficos
Autores principales:	Drake, Eric J., Miller, Bradley R., Shi, Ce, Tarrasch, Jeffrey T., Sundlov, Jesse A., Allen, C. Leigh, Skiniotis, Georgios, Aldrich, Courtney C., Gulick, Andrew M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843164/ https://www.ncbi.nlm.nih.gov/pubmed/26762461 http://dx.doi.org/10.1038/nature16163

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