Development of Human‐Like Advanced Coronary Plaques in Low‐Density Lipoprotein Receptor Knockout Pigs and Justification for Statin Treatment Before Formation of Atherosclerotic Plaques

BACKGROUND: Although clinical trials have proved that statin can be used prophylactically against cardiovascular events, the direct effects of statin on plaque development are not well understood. We generated low‐density lipoprotein receptor knockout (LDLR (−/−)) pigs to study the effects of early...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yuxin, Fuchimoto, Daiichiro, Sudo, Mitsumasa, Haruta, Hironori, Lin, Qing‐Fei, Takayama, Tadateru, Morita, Shotaro, Nochi, Tomonori, Suzuki, Shunichi, Sembon, Shoichiro, Nakai, Michiko, Kojima, Misaki, Iwamoto, Masaki, Hashimoto, Michiko, Yoda, Shunichi, Kunimoto, Satoshi, Hiro, Takafumi, Matsumoto, Taro, Mitsumata, Masako, Sugitani, Masahiko, Saito, Satoshi, Hirayama, Atsushi, Onishi, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843535/
https://www.ncbi.nlm.nih.gov/pubmed/27091180
http://dx.doi.org/10.1161/JAHA.115.002779

Ejemplares similares

Ejemplares similares