Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the mole...

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Detalles Bibliográficos
Autores principales: Burslem, George M., Kyle, Hannah F., Breeze, Alexander L., Edwards, Thomas A., Nelson, Adam, Warriner, Stuart L., Wilson, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843846/
https://www.ncbi.nlm.nih.gov/pubmed/27009828
http://dx.doi.org/10.1039/c6cc01812b
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author Burslem, George M.
Kyle, Hannah F.
Breeze, Alexander L.
Edwards, Thomas A.
Nelson, Adam
Warriner, Stuart L.
Wilson, Andrew J.
author_facet Burslem, George M.
Kyle, Hannah F.
Breeze, Alexander L.
Edwards, Thomas A.
Nelson, Adam
Warriner, Stuart L.
Wilson, Andrew J.
author_sort Burslem, George M.
collection PubMed
description Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the molecular recognition profile of the p300 binding sequence of HIF-1α from which it is derived.
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spelling pubmed-48438462016-05-09 Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics Burslem, George M. Kyle, Hannah F. Breeze, Alexander L. Edwards, Thomas A. Nelson, Adam Warriner, Stuart L. Wilson, Andrew J. Chem Commun (Camb) Chemistry Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the molecular recognition profile of the p300 binding sequence of HIF-1α from which it is derived. Royal Society of Chemistry 2016-04-21 2016-03-24 /pmc/articles/PMC4843846/ /pubmed/27009828 http://dx.doi.org/10.1039/c6cc01812b Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Burslem, George M.
Kyle, Hannah F.
Breeze, Alexander L.
Edwards, Thomas A.
Nelson, Adam
Warriner, Stuart L.
Wilson, Andrew J.
Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics
title Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics
title_full Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics
title_fullStr Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics
title_full_unstemmed Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics
title_short Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics
title_sort towards “bionic” proteins: replacement of continuous sequences from hif-1α with proteomimetics to create functional p300 binding hif-1α mimics
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843846/
https://www.ncbi.nlm.nih.gov/pubmed/27009828
http://dx.doi.org/10.1039/c6cc01812b
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