Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the mole...

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Detalles Bibliográficos
Autores principales: Burslem, George M., Kyle, Hannah F., Breeze, Alexander L., Edwards, Thomas A., Nelson, Adam, Warriner, Stuart L., Wilson, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843846/
https://www.ncbi.nlm.nih.gov/pubmed/27009828
http://dx.doi.org/10.1039/c6cc01812b

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