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The history of fever, leukocytic pyrogen and interleukin-1
There has been great progress in the 30 y since the reporting in 1984 of the cDNA for interleukin1 (IL1) β in the human and IL1α in the mouse. However, the history of IL1 begins in the early 1940s with investigations into the nature of an endogenous fever-producing protein released rabbit peritoneal...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Taylor & Francis
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843879/ https://www.ncbi.nlm.nih.gov/pubmed/27226996 http://dx.doi.org/10.1080/23328940.2015.1017086 |
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author | Dinarello, Charles A |
author_facet | Dinarello, Charles A |
author_sort | Dinarello, Charles A |
collection | PubMed |
description | There has been great progress in the 30 y since the reporting in 1984 of the cDNA for interleukin1 (IL1) β in the human and IL1α in the mouse. However, the history of IL1 begins in the early 1940s with investigations into the nature of an endogenous fever-producing protein released rabbit peritoneal neutrophils. Most researchers in immunology today are unaware that the field of cytokines, particularly the field of inflammatory cytokines. Toll-like receptors and innate immunity traces back to studies on fever. Researchers in infectious diseases wanted to know about an endogenous protein that caused fever, independent of infection. The endogenous fever-producing protein was called by various names: granulocyte, endogenous or leukocytic pyrogen. It is a fascinating and sometimes controversial story for biology and medicine and for the treatment of inflammatory diseases. Few imagined that this fever-producing protein would play such a major role in nearly every cell and in most diseases. This paper reviews the true background and milestones of interleukin1 from the purification of leukocytic pyrogen to the first cDNA of IL1β and the validation of cytokine biology from ill-defined factors to its present day importance. |
format | Online Article Text |
id | pubmed-4843879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-48438792016-05-25 The history of fever, leukocytic pyrogen and interleukin-1 Dinarello, Charles A Temperature (Austin) Legacy - Commissioned There has been great progress in the 30 y since the reporting in 1984 of the cDNA for interleukin1 (IL1) β in the human and IL1α in the mouse. However, the history of IL1 begins in the early 1940s with investigations into the nature of an endogenous fever-producing protein released rabbit peritoneal neutrophils. Most researchers in immunology today are unaware that the field of cytokines, particularly the field of inflammatory cytokines. Toll-like receptors and innate immunity traces back to studies on fever. Researchers in infectious diseases wanted to know about an endogenous protein that caused fever, independent of infection. The endogenous fever-producing protein was called by various names: granulocyte, endogenous or leukocytic pyrogen. It is a fascinating and sometimes controversial story for biology and medicine and for the treatment of inflammatory diseases. Few imagined that this fever-producing protein would play such a major role in nearly every cell and in most diseases. This paper reviews the true background and milestones of interleukin1 from the purification of leukocytic pyrogen to the first cDNA of IL1β and the validation of cytokine biology from ill-defined factors to its present day importance. Taylor & Francis 2015-04-14 /pmc/articles/PMC4843879/ /pubmed/27226996 http://dx.doi.org/10.1080/23328940.2015.1017086 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Legacy - Commissioned Dinarello, Charles A The history of fever, leukocytic pyrogen and interleukin-1 |
title | The history of fever, leukocytic pyrogen and interleukin-1 |
title_full | The history of fever, leukocytic pyrogen and interleukin-1 |
title_fullStr | The history of fever, leukocytic pyrogen and interleukin-1 |
title_full_unstemmed | The history of fever, leukocytic pyrogen and interleukin-1 |
title_short | The history of fever, leukocytic pyrogen and interleukin-1 |
title_sort | history of fever, leukocytic pyrogen and interleukin-1 |
topic | Legacy - Commissioned |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843879/ https://www.ncbi.nlm.nih.gov/pubmed/27226996 http://dx.doi.org/10.1080/23328940.2015.1017086 |
work_keys_str_mv | AT dinarellocharlesa thehistoryoffeverleukocyticpyrogenandinterleukin1 AT dinarellocharlesa historyoffeverleukocyticpyrogenandinterleukin1 |