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Platelet-activating factor is a potent pyrogen and cryogen, but it does not mediate lipopolysaccharide fever or hypothermia

We examined whether platelet-activating factor (PAF) and its receptor mediate lipopolysaccharide (LPS)-induced fever and hypothermia in rats. Two highly potent, structurally distinct antagonists of the PAF receptor, CV6209 and WEB2086, were used. At a neutral ambient temperature (T(a)) of 30ºC, admi...

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Detalles Bibliográficos
Autores principales:	Steiner, Alexandre A, Romanovsky, Andrej A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843927/ https://www.ncbi.nlm.nih.gov/pubmed/27227073 http://dx.doi.org/10.1080/23328940.2015.1030540

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