Cargando…

Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) reduces neonatal hypoxic‐ischaemic brain damage

Hypoxic‐ischaemic encephalopathy is a leading cause of child death, with high mortality and morbidity, including cerebral palsy, epilepsy and cognitive disabilities. Hypoxia‐ischaemia (HI) strongly up‐regulates Signal Transducer and Activator of Transcription 3 (STAT3) in the immature brain. Our aim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hristova, Mariya, Rocha‐Ferreira, Eridan, Fontana, Xavier, Thei, Laura, Buckle, Rheanan, Christou, Melina, Hompoonsup, Supanida, Gostelow, Naomi, Raivich, Gennadij, Peebles, Donald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	ORIGINAL ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843952/ https://www.ncbi.nlm.nih.gov/pubmed/26669927 http://dx.doi.org/10.1111/jnc.13490

Ejemplares similares

Extracellular signal‐regulated kinase 2 has duality in function between neuronal and astrocyte expression following neonatal hypoxic–ischaemic cerebral injury
por: Thei, Laura, et al.
Publicado: (2018)

Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates
por: Lange, Sigrun, et al.
Publicado: (2014)

Plasticity in the Neonatal Brain following Hypoxic-Ischaemic Injury
por: Rocha-Ferreira, Eridan, et al.
Publicado: (2016)

The duration of hypothermia affects short-term neuroprotection in a mouse model of neonatal hypoxic ischaemic injury
por: Rocha-Ferreira, Eridan, et al.
Publicado: (2018)

The role of different strain backgrounds in bacterial endotoxin-mediated sensitization to neonatal hypoxic–ischemic brain damage
por: Rocha-Ferreira, E., et al.
Publicado: (2015)

Current Therapies for Neonatal Hypoxic–Ischaemic and Infection-Sensitised Hypoxic–Ischaemic Brain Damage
por: Tetorou, Konstantina, et al.
Publicado: (2021)

c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling
por: Fontana, Xavier, et al.
Publicado: (2012)

No transcriptional evidence for active Na(v) channels in two classes of cancer cell
por: Hompoonsup, Supanida, et al.
Publicado: (2019)

Activating Transcription Factor 3 and the Nervous System
por: Hunt, David, et al.
Publicado: (2012)

TNF gene deletion prevents lipopolysaccharide-mediated sensitisation of the neonatal mouse brain to hypoxic-ischaemic insult
por: Sahota, A, et al.
Publicado: (2012)

Role of Transcription Factors in Peripheral Nerve Regeneration
por: Patodia, Smriti, et al.
Publicado: (2012)

Role of Microglia and Macrophages in Eae
por: Raivich, Gennadij, et al.
Publicado: (2005)

Neuronal c-Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N-terminus are moderate
por: Ruff, Crystal A, et al.
Publicado: (2012)

Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy
por: Rocha-Ferreira, Eridan, et al.
Publicado: (2018)

Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy
por: Rawlinson, Charlotte, et al.
Publicado: (2020)

Antimicrobial Peptides and Complement in Neonatal Hypoxia-Ischemia Induced Brain Damage
por: Rocha-Ferreira, Eridan, et al.
Publicado: (2015)

Curcumin: Novel Treatment in Neonatal Hypoxic-Ischemic Brain Injury
por: Rocha-Ferreira, Eridan, et al.
Publicado: (2019)

Patterns of neonatal hypoxic–ischaemic brain injury
por: de Vries, Linda S., et al.
Publicado: (2010)

The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia
por: Przanowski, Piotr, et al.
Publicado: (2013)

Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes
por: Madani, Aisha Y., et al.
Publicado: (2021)

Placental, Matrilineal, and Epigenetic Mechanisms Promoting Environmentally Adaptive Development of the Mammalian Brain
por: Broad, Kevin D., et al.
Publicado: (2016)

Analysis of Radiation Toxicity in Mammalian Cells Stably Transduced with Mitochondrial Stat3
por: Zanin, Alisa, et al.
Publicado: (2023)

Signal transducer and activator of transcription 3 (STAT3) signaling in retinal pigment epithelium cells
por: Patel, Amit K, et al.
Publicado: (2013)

Signal transducer and activator of transcription 3 (STAT3) promoter methylation and expression in pituitary adenoma
por: Valiulyte, Indre, et al.
Publicado: (2017)

Rationale for the Use of Cord Blood in Hypoxic-Ischaemic Encephalopathy
por: Zdolińska-Malinowska, Izabela, et al.
Publicado: (2022)

Evolution of early cerebral NIRS in hypoxic ischaemic encephalopathy
por: Garvey, Aisling A., et al.
Publicado: (2022)

Targeting constitutively-activated STAT3 in hypoxic ovarian cancer, using a novel STAT3 inhibitor
por: McCann, Georgia A., et al.
Publicado: (2014)

The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies
por: Arora, Loukik, et al.
Publicado: (2018)

Evaluation of quantitative assays for the identification of direct signal transducer and activator of transcription 3 (STAT3) inhibitors
por: Furtek, Steffanie L., et al.
Publicado: (2016)

Apotransferrin-induced recovery after hypoxic/ischaemic injury on myelination
por: Guardia Clausi, Mariano, et al.
Publicado: (2010)

Breastfeeding and swallowing in a neonate with mild hypoxic-ischaemic encephalopathy
por: Krüger, Esedra, et al.
Publicado: (2017)

Erratum to: The Jun-dependent axon regeneration gene program: Jun promotes regeneration over plasticity
por: Mason, Matthew R J, et al.
Publicado: (2022)

The Jun-dependent axon regeneration gene program: Jun promotes regeneration over plasticity
por: Mason, Matthew R J, et al.
Publicado: (2021)

Acacetin Inhibits the Growth of STAT3-Activated DU145 Prostate Cancer Cells by Directly Binding to Signal Transducer and Activator of Transcription 3 (STAT3)
por: Yun, Sun, et al.
Publicado: (2021)

Therapeutic Targeting of STAT3 (Signal Transducers and Activators of Transcription 3) Pathway Inhibits Experimental Autoimmune Uveitis
por: Yu, Cheng-Rong, et al.
Publicado: (2012)

Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3)
por: Gargantilla, Marta, et al.
Publicado: (2022)

Essential Role of Signal Transducer and Activator of Transcription (Stat)5a but Not Stat5b for Flt3-Dependent Signaling
por: Zhang, Shuli, et al.
Publicado: (2000)

Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation
por: Aparicio-Siegmund, Samadhi, et al.
Publicado: (2014)

New possibilities for neuroprotection in neonatal hypoxic-ischemic encephalopathy
por: Victor, Suresh, et al.
Publicado: (2021)

The Metabolomic Profile of Umbilical Cord Blood in Neonatal Hypoxic Ischaemic Encephalopathy
por: Walsh, Brian H., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_0v51psubpiq84qt7d44mb1d49g