4 Hz oscillations synchronize prefrontal-amygdala circuits during fear behaviour

Fear expression relies on the coordinated activity of prefrontal and amygdala circuits, yet the mechanisms allowing long-range network synchronization during fear remain unknown. Using a combination of extracellular recordings, pharmacological, and optogenetic manipulations we report that freezing,...

Descripción completa

Detalles Bibliográficos
Autores principales: Karalis, Nikolaos, Dejean, Cyril, Chaudun, Fabrice, Khoder, Suzana, Rozeske, Robert R., Wurtz, Hélène, Bagur, Sophie, Benchenane, Karim, Sirota, Anton, Courtin, Julien, Herry, Cyril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843971/
https://www.ncbi.nlm.nih.gov/pubmed/26878674
http://dx.doi.org/10.1038/nn.4251
_version_ 1782428708978556928
author Karalis, Nikolaos
Dejean, Cyril
Chaudun, Fabrice
Khoder, Suzana
Rozeske, Robert R.
Wurtz, Hélène
Bagur, Sophie
Benchenane, Karim
Sirota, Anton
Courtin, Julien
Herry, Cyril
author_facet Karalis, Nikolaos
Dejean, Cyril
Chaudun, Fabrice
Khoder, Suzana
Rozeske, Robert R.
Wurtz, Hélène
Bagur, Sophie
Benchenane, Karim
Sirota, Anton
Courtin, Julien
Herry, Cyril
author_sort Karalis, Nikolaos
collection PubMed
description Fear expression relies on the coordinated activity of prefrontal and amygdala circuits, yet the mechanisms allowing long-range network synchronization during fear remain unknown. Using a combination of extracellular recordings, pharmacological, and optogenetic manipulations we report that freezing, a behavioural expression of fear, temporally coincides with the development of sustained, internally generated 4 Hz oscillations within prefrontal-amygdala circuits. 4 Hz oscillations predict freezing onset and offset and synchronize prefrontal-amygdala circuits. Optogenetic induction of prefrontal 4 Hz oscillations coordinates prefrontal-amygdala activity and elicits fear behaviour. These results unravel a novel sustained oscillatory mechanism mediating prefrontal-amygdala coupling during fear behaviour.
format Online
Article
Text
id pubmed-4843971
institution National Center for Biotechnology Information
language English
publishDate 2016
record_format MEDLINE/PubMed
spelling pubmed-48439712016-09-22 4 Hz oscillations synchronize prefrontal-amygdala circuits during fear behaviour Karalis, Nikolaos Dejean, Cyril Chaudun, Fabrice Khoder, Suzana Rozeske, Robert R. Wurtz, Hélène Bagur, Sophie Benchenane, Karim Sirota, Anton Courtin, Julien Herry, Cyril Nat Neurosci Article Fear expression relies on the coordinated activity of prefrontal and amygdala circuits, yet the mechanisms allowing long-range network synchronization during fear remain unknown. Using a combination of extracellular recordings, pharmacological, and optogenetic manipulations we report that freezing, a behavioural expression of fear, temporally coincides with the development of sustained, internally generated 4 Hz oscillations within prefrontal-amygdala circuits. 4 Hz oscillations predict freezing onset and offset and synchronize prefrontal-amygdala circuits. Optogenetic induction of prefrontal 4 Hz oscillations coordinates prefrontal-amygdala activity and elicits fear behaviour. These results unravel a novel sustained oscillatory mechanism mediating prefrontal-amygdala coupling during fear behaviour. 2016-02-15 2016-04 /pmc/articles/PMC4843971/ /pubmed/26878674 http://dx.doi.org/10.1038/nn.4251 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Karalis, Nikolaos
Dejean, Cyril
Chaudun, Fabrice
Khoder, Suzana
Rozeske, Robert R.
Wurtz, Hélène
Bagur, Sophie
Benchenane, Karim
Sirota, Anton
Courtin, Julien
Herry, Cyril
4 Hz oscillations synchronize prefrontal-amygdala circuits during fear behaviour
title 4 Hz oscillations synchronize prefrontal-amygdala circuits during fear behaviour
title_full 4 Hz oscillations synchronize prefrontal-amygdala circuits during fear behaviour
title_fullStr 4 Hz oscillations synchronize prefrontal-amygdala circuits during fear behaviour
title_full_unstemmed 4 Hz oscillations synchronize prefrontal-amygdala circuits during fear behaviour
title_short 4 Hz oscillations synchronize prefrontal-amygdala circuits during fear behaviour
title_sort 4 hz oscillations synchronize prefrontal-amygdala circuits during fear behaviour
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843971/
https://www.ncbi.nlm.nih.gov/pubmed/26878674
http://dx.doi.org/10.1038/nn.4251
work_keys_str_mv AT karalisnikolaos 4hzoscillationssynchronizeprefrontalamygdalacircuitsduringfearbehaviour
AT dejeancyril 4hzoscillationssynchronizeprefrontalamygdalacircuitsduringfearbehaviour
AT chaudunfabrice 4hzoscillationssynchronizeprefrontalamygdalacircuitsduringfearbehaviour
AT khodersuzana 4hzoscillationssynchronizeprefrontalamygdalacircuitsduringfearbehaviour
AT rozeskerobertr 4hzoscillationssynchronizeprefrontalamygdalacircuitsduringfearbehaviour
AT wurtzhelene 4hzoscillationssynchronizeprefrontalamygdalacircuitsduringfearbehaviour
AT bagursophie 4hzoscillationssynchronizeprefrontalamygdalacircuitsduringfearbehaviour
AT benchenanekarim 4hzoscillationssynchronizeprefrontalamygdalacircuitsduringfearbehaviour
AT sirotaanton 4hzoscillationssynchronizeprefrontalamygdalacircuitsduringfearbehaviour
AT courtinjulien 4hzoscillationssynchronizeprefrontalamygdalacircuitsduringfearbehaviour
AT herrycyril 4hzoscillationssynchronizeprefrontalamygdalacircuitsduringfearbehaviour

Ejemplares similares