Circulating Differentially Methylated Amylin DNA as a Biomarker of β-Cell Loss in Type 1 Diabetes

In type 1 diabetes (T1D), β-cell loss is silent during disease progression. Methylation-sensitive quantitative real-time PCR (qPCR) of β-cell-derived DNA in the blood can serve as a biomarker of β-cell death in T1D. Amylin is highly expressed by β-cells in the islet. Here we examined whether demethy...

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Detalles Bibliográficos
Autores principales: Olsen, John A., Kenna, Lauren A., Spelios, Michael G., Hessner, Martin J., Akirav, Eitan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844136/
https://www.ncbi.nlm.nih.gov/pubmed/27111653
http://dx.doi.org/10.1371/journal.pone.0152662

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