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Detection of BRAF Mutations Using a Fully Automated Platform and Comparison with High Resolution Melting, Real-Time Allele Specific Amplification, Immunohistochemistry and Next Generation Sequencing Assays, for Patients with Metastatic Melanoma

BACKGROUND: Metastatic melanoma is a severe disease with one of the highest mortality rate in skin diseases. Overall survival has significantly improved with immunotherapy and targeted therapies. Kinase inhibitors targeting BRAF V600 showed promising results. BRAF genotyping is mandatory for the pre...

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Detalles Bibliográficos
Autores principales:	Harlé, Alexandre, Salleron, Julia, Franczak, Claire, Dubois, Cindy, Filhine-Tressarieu, Pierre, Leroux, Agnès, Merlin, Jean-Louis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844167/ https://www.ncbi.nlm.nih.gov/pubmed/27111917 http://dx.doi.org/10.1371/journal.pone.0153576

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