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Site-specific Proteasome Phosphorylation Controls Cell Proliferation and Tumorigenesis

Despite the fundamental importance of proteasomal degradation in cells, little is known about whether and how the 26S proteasome itself is regulated in coordination with various physiological processes. Here we show that the proteasome is dynamically phosphorylated during cell cycle at Thr25 of the...

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Detalles Bibliográficos
Autores principales: Guo, Xing, Wang, Xiaorong, Wang, Zhiping, Banerjee, Sourav, Yang, Jing, Huang, Lan, Dixon, Jack E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844191/
https://www.ncbi.nlm.nih.gov/pubmed/26655835
http://dx.doi.org/10.1038/ncb3289