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CFTR Activator Increases Intestinal Fluid Secretion and Normalizes Stool Output in a Mouse Model of Constipation
BACKGROUND & AIMS: Constipation is a common clinical problem that negatively impacts quality of life and is associated with significant health care costs. Activation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the primary pathway that drives fluid secret...
Autores principales: | Cil, Onur, Phuan, Puay-Wah, Lee, Sujin, Tan, Joseph, Haggie, Peter M., Levin, Marc H., Sun, Liang, Thiagarajah, Jay R., Ma, Tonghui, Verkman, Alan S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844355/ https://www.ncbi.nlm.nih.gov/pubmed/27127798 http://dx.doi.org/10.1016/j.jcmgh.2015.12.010 |
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