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CFTR Activator Increases Intestinal Fluid Secretion and Normalizes Stool Output in a Mouse Model of Constipation

BACKGROUND & AIMS: Constipation is a common clinical problem that negatively impacts quality of life and is associated with significant health care costs. Activation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the primary pathway that drives fluid secret...

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Detalles Bibliográficos
Autores principales:	Cil, Onur, Phuan, Puay-Wah, Lee, Sujin, Tan, Joseph, Haggie, Peter M., Levin, Marc H., Sun, Liang, Thiagarajah, Jay R., Ma, Tonghui, Verkman, Alan S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844355/ https://www.ncbi.nlm.nih.gov/pubmed/27127798 http://dx.doi.org/10.1016/j.jcmgh.2015.12.010

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