In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines

In the present investigation, we examined the cytotoxic effect of methanolic extract from Origanum vulgare on HCT-116 and MDA-MB-231 cell line in vitro. In order to determine the cytotoxic effects we used an MTT viability assay. The results showed that cell growth is significantly lower in extract t...

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Autores principales: Grbović, Filip, Stanković, Milan S., Ćurčić, Milena, Đorđević, Nataša, Šeklić, Dragana, Topuzović, Marina, Marković, Snežana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844373/
https://www.ncbi.nlm.nih.gov/pubmed/27137381
http://dx.doi.org/10.3390/plants2030371
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author Grbović, Filip
Stanković, Milan S.
Ćurčić, Milena
Đorđević, Nataša
Šeklić, Dragana
Topuzović, Marina
Marković, Snežana
author_facet Grbović, Filip
Stanković, Milan S.
Ćurčić, Milena
Đorđević, Nataša
Šeklić, Dragana
Topuzović, Marina
Marković, Snežana
author_sort Grbović, Filip
collection PubMed
description In the present investigation, we examined the cytotoxic effect of methanolic extract from Origanum vulgare on HCT-116 and MDA-MB-231 cell line in vitro. In order to determine the cytotoxic effects we used an MTT viability assay. The results showed that cell growth is significantly lower in extract treated cells compared to untreated control. The effect of inhibition of cell growth was higher in the treatment of HCT-116 cell line than in MDA-MB-231. Based on the results it is determined that O. vulgare is a significant source of biologically active substances that have cytotoxic and antiproliferative activity in vitro.
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spelling pubmed-48443732016-04-29 In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines Grbović, Filip Stanković, Milan S. Ćurčić, Milena Đorđević, Nataša Šeklić, Dragana Topuzović, Marina Marković, Snežana Plants (Basel) Article In the present investigation, we examined the cytotoxic effect of methanolic extract from Origanum vulgare on HCT-116 and MDA-MB-231 cell line in vitro. In order to determine the cytotoxic effects we used an MTT viability assay. The results showed that cell growth is significantly lower in extract treated cells compared to untreated control. The effect of inhibition of cell growth was higher in the treatment of HCT-116 cell line than in MDA-MB-231. Based on the results it is determined that O. vulgare is a significant source of biologically active substances that have cytotoxic and antiproliferative activity in vitro. MDPI 2013-06-25 /pmc/articles/PMC4844373/ /pubmed/27137381 http://dx.doi.org/10.3390/plants2030371 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Grbović, Filip
Stanković, Milan S.
Ćurčić, Milena
Đorđević, Nataša
Šeklić, Dragana
Topuzović, Marina
Marković, Snežana
In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines
title In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines
title_full In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines
title_fullStr In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines
title_full_unstemmed In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines
title_short In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines
title_sort in vitro cytotoxic activity of origanum vulgare l. on hct-116 and mda-mb-231 cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844373/
https://www.ncbi.nlm.nih.gov/pubmed/27137381
http://dx.doi.org/10.3390/plants2030371
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