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Overexpression of BUB1B contributes to progression of prostate cancer and predicts poor outcome in patients with prostate cancer

BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) is a member of the spindle assembly checkpoint protein family, which has been proven to be associated with many kinds of cancers. The aim of this study was to investigate whether BUB1B was correlated with progression and prognosis in patients...

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Autores principales: Fu, Xin, Chen, Guo, Cai, Zhi-duan, Wang, Cong, Liu, Ze-zhen, Lin, Zhuo-yuan, Wu, Yong-ding, Liang, Yu-xiang, Han, Zhao-dong, Liu, Jun-chen, Zhong, Wei-De
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844448/
https://www.ncbi.nlm.nih.gov/pubmed/27143916
http://dx.doi.org/10.2147/OTT.S101994
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author Fu, Xin
Chen, Guo
Cai, Zhi-duan
Wang, Cong
Liu, Ze-zhen
Lin, Zhuo-yuan
Wu, Yong-ding
Liang, Yu-xiang
Han, Zhao-dong
Liu, Jun-chen
Zhong, Wei-De
author_facet Fu, Xin
Chen, Guo
Cai, Zhi-duan
Wang, Cong
Liu, Ze-zhen
Lin, Zhuo-yuan
Wu, Yong-ding
Liang, Yu-xiang
Han, Zhao-dong
Liu, Jun-chen
Zhong, Wei-De
author_sort Fu, Xin
collection PubMed
description BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) is a member of the spindle assembly checkpoint protein family, which has been proven to be associated with many kinds of cancers. The aim of this study was to investigate whether BUB1B was correlated with progression and prognosis in patients with prostate cancer (PCa) and how BUB1B regulated the proliferation, migration, and invasion of PCa cell lines. Compared to benign prostate cells and tissues, both messenger RNA and protein expressions of BUB1B were statistically increased in PCa cell lines and tumor tissues. In vitro studies revealed that BUB1B overexpression enhanced the proliferation, migration, and invasion ability of PCa cell lines, whereas depletion of BUB1B did not affect the cell functions. Microarray analysis showed the positive staining of BUB1B was upregulated in the higher Gleason score group, which also correlated with advanced clinicopathological stage, higher serum prostate-specific antigen, metastasis, overall survival, and prostate-specific antigen failure. Furthermore, the survival analysis indicated that high expression of BUB1B was an independent predictor for shorter biochemical recurrence-free survival, which had no effect on overall survival. BUB1B plays an important role in tumor growth and progression, which can lead to its use as a potential biomarker for the diagnosis and prognosis of PCa.
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spelling pubmed-48444482016-05-03 Overexpression of BUB1B contributes to progression of prostate cancer and predicts poor outcome in patients with prostate cancer Fu, Xin Chen, Guo Cai, Zhi-duan Wang, Cong Liu, Ze-zhen Lin, Zhuo-yuan Wu, Yong-ding Liang, Yu-xiang Han, Zhao-dong Liu, Jun-chen Zhong, Wei-De Onco Targets Ther Original Research BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) is a member of the spindle assembly checkpoint protein family, which has been proven to be associated with many kinds of cancers. The aim of this study was to investigate whether BUB1B was correlated with progression and prognosis in patients with prostate cancer (PCa) and how BUB1B regulated the proliferation, migration, and invasion of PCa cell lines. Compared to benign prostate cells and tissues, both messenger RNA and protein expressions of BUB1B were statistically increased in PCa cell lines and tumor tissues. In vitro studies revealed that BUB1B overexpression enhanced the proliferation, migration, and invasion ability of PCa cell lines, whereas depletion of BUB1B did not affect the cell functions. Microarray analysis showed the positive staining of BUB1B was upregulated in the higher Gleason score group, which also correlated with advanced clinicopathological stage, higher serum prostate-specific antigen, metastasis, overall survival, and prostate-specific antigen failure. Furthermore, the survival analysis indicated that high expression of BUB1B was an independent predictor for shorter biochemical recurrence-free survival, which had no effect on overall survival. BUB1B plays an important role in tumor growth and progression, which can lead to its use as a potential biomarker for the diagnosis and prognosis of PCa. Dove Medical Press 2016-04-15 /pmc/articles/PMC4844448/ /pubmed/27143916 http://dx.doi.org/10.2147/OTT.S101994 Text en © 2016 Fu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Fu, Xin
Chen, Guo
Cai, Zhi-duan
Wang, Cong
Liu, Ze-zhen
Lin, Zhuo-yuan
Wu, Yong-ding
Liang, Yu-xiang
Han, Zhao-dong
Liu, Jun-chen
Zhong, Wei-De
Overexpression of BUB1B contributes to progression of prostate cancer and predicts poor outcome in patients with prostate cancer
title Overexpression of BUB1B contributes to progression of prostate cancer and predicts poor outcome in patients with prostate cancer
title_full Overexpression of BUB1B contributes to progression of prostate cancer and predicts poor outcome in patients with prostate cancer
title_fullStr Overexpression of BUB1B contributes to progression of prostate cancer and predicts poor outcome in patients with prostate cancer
title_full_unstemmed Overexpression of BUB1B contributes to progression of prostate cancer and predicts poor outcome in patients with prostate cancer
title_short Overexpression of BUB1B contributes to progression of prostate cancer and predicts poor outcome in patients with prostate cancer
title_sort overexpression of bub1b contributes to progression of prostate cancer and predicts poor outcome in patients with prostate cancer
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844448/
https://www.ncbi.nlm.nih.gov/pubmed/27143916
http://dx.doi.org/10.2147/OTT.S101994
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