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Bone Fragility in Turner Syndrome: Mechanisms and Prevention Strategies

Bone fragility is recognized as one of the major comorbidities in Turner syndrome (TS). The mechanisms underlying bone impairment in affected patients are not clearly elucidated, but estrogen deficiency and X-chromosomal abnormalities represent important factors. Moreover, although many girls with T...

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Autores principales: Faienza, Maria Felicia, Ventura, Annamaria, Colucci, Silvia, Cavallo, Luciano, Grano, Maria, Brunetti, Giacomina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844601/
https://www.ncbi.nlm.nih.gov/pubmed/27199891
http://dx.doi.org/10.3389/fendo.2016.00034
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author Faienza, Maria Felicia
Ventura, Annamaria
Colucci, Silvia
Cavallo, Luciano
Grano, Maria
Brunetti, Giacomina
author_facet Faienza, Maria Felicia
Ventura, Annamaria
Colucci, Silvia
Cavallo, Luciano
Grano, Maria
Brunetti, Giacomina
author_sort Faienza, Maria Felicia
collection PubMed
description Bone fragility is recognized as one of the major comorbidities in Turner syndrome (TS). The mechanisms underlying bone impairment in affected patients are not clearly elucidated, but estrogen deficiency and X-chromosomal abnormalities represent important factors. Moreover, although many girls with TS undergo recombinant growth hormone therapy to treat short stature, the efficacy of this treatment on bone mineral density is controversial. The present review will focus on bone fragility in subjects with TS, providing an overview on the pathogenic mechanisms and some prevention strategies.
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spelling pubmed-48446012016-05-19 Bone Fragility in Turner Syndrome: Mechanisms and Prevention Strategies Faienza, Maria Felicia Ventura, Annamaria Colucci, Silvia Cavallo, Luciano Grano, Maria Brunetti, Giacomina Front Endocrinol (Lausanne) Endocrinology Bone fragility is recognized as one of the major comorbidities in Turner syndrome (TS). The mechanisms underlying bone impairment in affected patients are not clearly elucidated, but estrogen deficiency and X-chromosomal abnormalities represent important factors. Moreover, although many girls with TS undergo recombinant growth hormone therapy to treat short stature, the efficacy of this treatment on bone mineral density is controversial. The present review will focus on bone fragility in subjects with TS, providing an overview on the pathogenic mechanisms and some prevention strategies. Frontiers Media S.A. 2016-04-26 /pmc/articles/PMC4844601/ /pubmed/27199891 http://dx.doi.org/10.3389/fendo.2016.00034 Text en Copyright © 2016 Faienza, Ventura, Colucci, Cavallo, Grano and Brunetti. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Faienza, Maria Felicia
Ventura, Annamaria
Colucci, Silvia
Cavallo, Luciano
Grano, Maria
Brunetti, Giacomina
Bone Fragility in Turner Syndrome: Mechanisms and Prevention Strategies
title Bone Fragility in Turner Syndrome: Mechanisms and Prevention Strategies
title_full Bone Fragility in Turner Syndrome: Mechanisms and Prevention Strategies
title_fullStr Bone Fragility in Turner Syndrome: Mechanisms and Prevention Strategies
title_full_unstemmed Bone Fragility in Turner Syndrome: Mechanisms and Prevention Strategies
title_short Bone Fragility in Turner Syndrome: Mechanisms and Prevention Strategies
title_sort bone fragility in turner syndrome: mechanisms and prevention strategies
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844601/
https://www.ncbi.nlm.nih.gov/pubmed/27199891
http://dx.doi.org/10.3389/fendo.2016.00034
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