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Amygdala Regulation Following fMRI-Neurofeedback without Instructed Strategies
Within the field of functional magnetic resonance imaging (fMRI) neurofeedback, most studies provide subjects with instructions or suggest strategies to regulate a particular brain area, while other neuro-/biofeedback approaches often do not. This study is the first to investigate the hypothesis tha...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844623/ https://www.ncbi.nlm.nih.gov/pubmed/27199706 http://dx.doi.org/10.3389/fnhum.2016.00183 |
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author | Marxen, Michael Jacob, Mark J. Müller, Dirk K. Posse, Stefan Ackley, Elena Hellrung, Lydia Riedel, Philipp Bender, Stephan Epple, Robert Smolka, Michael N. |
author_facet | Marxen, Michael Jacob, Mark J. Müller, Dirk K. Posse, Stefan Ackley, Elena Hellrung, Lydia Riedel, Philipp Bender, Stephan Epple, Robert Smolka, Michael N. |
author_sort | Marxen, Michael |
collection | PubMed |
description | Within the field of functional magnetic resonance imaging (fMRI) neurofeedback, most studies provide subjects with instructions or suggest strategies to regulate a particular brain area, while other neuro-/biofeedback approaches often do not. This study is the first to investigate the hypothesis that subjects are able to utilize fMRI neurofeedback to learn to differentially modulate the fMRI signal from the bilateral amygdala congruent with the prescribed regulation direction without an instructed or suggested strategy and apply what they learned even when feedback is no longer available. Thirty-two subjects were included in the analysis. Data were collected at 3 Tesla using blood oxygenation level dependent (BOLD)-sensitivity optimized multi-echo EPI. Based on the mean contrast between up- and down-regulation in the amygdala in a post-training scan without feedback following three neurofeedback sessions, subjects were able to regulate their amygdala congruent with the prescribed directions with a moderate effect size of Cohen’s d = 0.43 (95% conf. int. 0.23–0.64). This effect size would be reduced, however, through stricter exclusion criteria for subjects that show alterations in respiration. Regulation capacity was positively correlated with subjective arousal ratings and negatively correlated with agreeableness and susceptibility to anger. A learning effect over the training sessions was only observed with end-of-block feedback (EoBF) but not with continuous feedback (trend). The results confirm the above hypothesis. Further studies are needed to compare effect sizes of regulation capacity for approaches with and without instructed strategies. |
format | Online Article Text |
id | pubmed-4844623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48446232016-05-19 Amygdala Regulation Following fMRI-Neurofeedback without Instructed Strategies Marxen, Michael Jacob, Mark J. Müller, Dirk K. Posse, Stefan Ackley, Elena Hellrung, Lydia Riedel, Philipp Bender, Stephan Epple, Robert Smolka, Michael N. Front Hum Neurosci Neuroscience Within the field of functional magnetic resonance imaging (fMRI) neurofeedback, most studies provide subjects with instructions or suggest strategies to regulate a particular brain area, while other neuro-/biofeedback approaches often do not. This study is the first to investigate the hypothesis that subjects are able to utilize fMRI neurofeedback to learn to differentially modulate the fMRI signal from the bilateral amygdala congruent with the prescribed regulation direction without an instructed or suggested strategy and apply what they learned even when feedback is no longer available. Thirty-two subjects were included in the analysis. Data were collected at 3 Tesla using blood oxygenation level dependent (BOLD)-sensitivity optimized multi-echo EPI. Based on the mean contrast between up- and down-regulation in the amygdala in a post-training scan without feedback following three neurofeedback sessions, subjects were able to regulate their amygdala congruent with the prescribed directions with a moderate effect size of Cohen’s d = 0.43 (95% conf. int. 0.23–0.64). This effect size would be reduced, however, through stricter exclusion criteria for subjects that show alterations in respiration. Regulation capacity was positively correlated with subjective arousal ratings and negatively correlated with agreeableness and susceptibility to anger. A learning effect over the training sessions was only observed with end-of-block feedback (EoBF) but not with continuous feedback (trend). The results confirm the above hypothesis. Further studies are needed to compare effect sizes of regulation capacity for approaches with and without instructed strategies. Frontiers Media S.A. 2016-04-26 /pmc/articles/PMC4844623/ /pubmed/27199706 http://dx.doi.org/10.3389/fnhum.2016.00183 Text en Copyright © 2016 Marxen, Jacob, Müller, Posse, Ackley, Hellrung, Riedel, Bender, Epple and Smolka. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Marxen, Michael Jacob, Mark J. Müller, Dirk K. Posse, Stefan Ackley, Elena Hellrung, Lydia Riedel, Philipp Bender, Stephan Epple, Robert Smolka, Michael N. Amygdala Regulation Following fMRI-Neurofeedback without Instructed Strategies |
title | Amygdala Regulation Following fMRI-Neurofeedback without Instructed Strategies |
title_full | Amygdala Regulation Following fMRI-Neurofeedback without Instructed Strategies |
title_fullStr | Amygdala Regulation Following fMRI-Neurofeedback without Instructed Strategies |
title_full_unstemmed | Amygdala Regulation Following fMRI-Neurofeedback without Instructed Strategies |
title_short | Amygdala Regulation Following fMRI-Neurofeedback without Instructed Strategies |
title_sort | amygdala regulation following fmri-neurofeedback without instructed strategies |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844623/ https://www.ncbi.nlm.nih.gov/pubmed/27199706 http://dx.doi.org/10.3389/fnhum.2016.00183 |
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