CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection

Double-strand breaks repaired by homologous recombination (HR) are first resected to form single-stranded DNA, which binds replication protein A (RPA). RPA attracts mediators that load the Rad51 filament to promote strand invasion, the defining feature of HR. How the resection machinery navigates nu...

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Detalles Bibliográficos
Autores principales: Zeng, Ming, Ren, Laifeng, Mizuno, Ken'Ichi, Nestoras, Konstantinos, Wang, Haibin, Tang, Zizhi, Guo, Liandi, Kong, Daochun, Hu, Qiwen, He, Qun, Du, Lilin, Carr, Antony M., Liu, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844679/
https://www.ncbi.nlm.nih.gov/pubmed/27098497
http://dx.doi.org/10.1038/ncomms11364

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