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Diffuse Spinal Leptomeningeal Spread of a Pilocytic Astrocytoma in a 3-year-old Child

Pilocytic astrocytomas correspond to low-grade gliomas and therefore metastasize exceedingly rare. However, pilocytic astrocytomas are able to and leptomeningeal dissemination may be seen. What are the treatment options of these cases? We present a case report of a 3-year-old child with a pilocytic...

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Autores principales: Alyeldien, Ameer, Teuber-Hanselmann, Sarah, Cheko, Azad, Höll, Tanja, Scholz, Martin, Petridis, Athanasios K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844811/
https://www.ncbi.nlm.nih.gov/pubmed/27162602
http://dx.doi.org/10.4081/cp.2016.813
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author Alyeldien, Ameer
Teuber-Hanselmann, Sarah
Cheko, Azad
Höll, Tanja
Scholz, Martin
Petridis, Athanasios K.
author_facet Alyeldien, Ameer
Teuber-Hanselmann, Sarah
Cheko, Azad
Höll, Tanja
Scholz, Martin
Petridis, Athanasios K.
author_sort Alyeldien, Ameer
collection PubMed
description Pilocytic astrocytomas correspond to low-grade gliomas and therefore metastasize exceedingly rare. However, pilocytic astrocytomas are able to and leptomeningeal dissemination may be seen. What are the treatment options of these cases? We present a case report of a 3-year-old child with a pilocytic astrocytoma of the optic chiasm with leptomeningeal dissemination of the spinal meninges. Partial resection of the cerebral tumor has been performed. Since the leptomeningeal dissemination was seen all over the spinal meninges, the child did not undergo further surgical treatment. A wait and watch strategy were followed. Chemotherapy was initiated, if a 25% tumor growth was seen. Leptomeningeal dissemination of a pilocytic astrocytoma is seen so infrequently that no standard therapy is established. Since these metastases may occur even up to 2 decades after primary tumor resection, long-term follow-up is indicated. In case of spinal metastases, surgical treatment should be performed if feasible. Otherwise observation should be possessed and/or chemotherapy should be initiated.
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spelling pubmed-48448112016-05-09 Diffuse Spinal Leptomeningeal Spread of a Pilocytic Astrocytoma in a 3-year-old Child Alyeldien, Ameer Teuber-Hanselmann, Sarah Cheko, Azad Höll, Tanja Scholz, Martin Petridis, Athanasios K. Clin Pract Case Report Pilocytic astrocytomas correspond to low-grade gliomas and therefore metastasize exceedingly rare. However, pilocytic astrocytomas are able to and leptomeningeal dissemination may be seen. What are the treatment options of these cases? We present a case report of a 3-year-old child with a pilocytic astrocytoma of the optic chiasm with leptomeningeal dissemination of the spinal meninges. Partial resection of the cerebral tumor has been performed. Since the leptomeningeal dissemination was seen all over the spinal meninges, the child did not undergo further surgical treatment. A wait and watch strategy were followed. Chemotherapy was initiated, if a 25% tumor growth was seen. Leptomeningeal dissemination of a pilocytic astrocytoma is seen so infrequently that no standard therapy is established. Since these metastases may occur even up to 2 decades after primary tumor resection, long-term follow-up is indicated. In case of spinal metastases, surgical treatment should be performed if feasible. Otherwise observation should be possessed and/or chemotherapy should be initiated. PAGEPress Publications, Pavia, Italy 2016-03-31 /pmc/articles/PMC4844811/ /pubmed/27162602 http://dx.doi.org/10.4081/cp.2016.813 Text en ©Copyright A. Alyeldien et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Alyeldien, Ameer
Teuber-Hanselmann, Sarah
Cheko, Azad
Höll, Tanja
Scholz, Martin
Petridis, Athanasios K.
Diffuse Spinal Leptomeningeal Spread of a Pilocytic Astrocytoma in a 3-year-old Child
title Diffuse Spinal Leptomeningeal Spread of a Pilocytic Astrocytoma in a 3-year-old Child
title_full Diffuse Spinal Leptomeningeal Spread of a Pilocytic Astrocytoma in a 3-year-old Child
title_fullStr Diffuse Spinal Leptomeningeal Spread of a Pilocytic Astrocytoma in a 3-year-old Child
title_full_unstemmed Diffuse Spinal Leptomeningeal Spread of a Pilocytic Astrocytoma in a 3-year-old Child
title_short Diffuse Spinal Leptomeningeal Spread of a Pilocytic Astrocytoma in a 3-year-old Child
title_sort diffuse spinal leptomeningeal spread of a pilocytic astrocytoma in a 3-year-old child
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844811/
https://www.ncbi.nlm.nih.gov/pubmed/27162602
http://dx.doi.org/10.4081/cp.2016.813
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