Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's Disease

In aged subjects, late-onset Alzheimer's disease (LOAD) starts in the lateral entorhinal allocortex where a failure of clearance mechanisms triggers an accumulation of neurotoxic amyloid-β(42) oligomers (Aβ(42)-os). In neurons and astrocytes, Aβ(42)-os enhance the transcription of Aβ precursor...

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Detalles Bibliográficos
Autores principales: Chiarini, Anna, Armato, Ubaldo, Liu, Daisong, Dal Prà, Ilaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844916/
https://www.ncbi.nlm.nih.gov/pubmed/27199760
http://dx.doi.org/10.3389/fphys.2016.00134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844916/
https://www.ncbi.nlm.nih.gov/pubmed/27199760
http://dx.doi.org/10.3389/fphys.2016.00134

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