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Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's Disease
In aged subjects, late-onset Alzheimer's disease (LOAD) starts in the lateral entorhinal allocortex where a failure of clearance mechanisms triggers an accumulation of neurotoxic amyloid-β(42) oligomers (Aβ(42)-os). In neurons and astrocytes, Aβ(42)-os enhance the transcription of Aβ precursor...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844916/ https://www.ncbi.nlm.nih.gov/pubmed/27199760 http://dx.doi.org/10.3389/fphys.2016.00134 |