Characterization of piRNAs across postnatal development in mouse brain

PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues– where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequenc...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghosheh, Yanal, Seridi, Loqmane, Ryu, Taewoo, Takahashi, Hazuki, Orlando, Valerio, Carninci, Piero, Ravasi, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844963/
https://www.ncbi.nlm.nih.gov/pubmed/27112104
http://dx.doi.org/10.1038/srep25039
_version_ 1782428851586990080
author Ghosheh, Yanal
Seridi, Loqmane
Ryu, Taewoo
Takahashi, Hazuki
Orlando, Valerio
Carninci, Piero
Ravasi, Timothy
author_facet Ghosheh, Yanal
Seridi, Loqmane
Ryu, Taewoo
Takahashi, Hazuki
Orlando, Valerio
Carninci, Piero
Ravasi, Timothy
author_sort Ghosheh, Yanal
collection PubMed
description PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues– where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.
format Online
Article
Text
id pubmed-4844963
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-48449632016-04-29 Characterization of piRNAs across postnatal development in mouse brain Ghosheh, Yanal Seridi, Loqmane Ryu, Taewoo Takahashi, Hazuki Orlando, Valerio Carninci, Piero Ravasi, Timothy Sci Rep Article PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues– where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs. Nature Publishing Group 2016-04-26 /pmc/articles/PMC4844963/ /pubmed/27112104 http://dx.doi.org/10.1038/srep25039 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Ghosheh, Yanal
Seridi, Loqmane
Ryu, Taewoo
Takahashi, Hazuki
Orlando, Valerio
Carninci, Piero
Ravasi, Timothy
Characterization of piRNAs across postnatal development in mouse brain
title Characterization of piRNAs across postnatal development in mouse brain
title_full Characterization of piRNAs across postnatal development in mouse brain
title_fullStr Characterization of piRNAs across postnatal development in mouse brain
title_full_unstemmed Characterization of piRNAs across postnatal development in mouse brain
title_short Characterization of piRNAs across postnatal development in mouse brain
title_sort characterization of pirnas across postnatal development in mouse brain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844963/
https://www.ncbi.nlm.nih.gov/pubmed/27112104
http://dx.doi.org/10.1038/srep25039
work_keys_str_mv AT ghoshehyanal characterizationofpirnasacrosspostnataldevelopmentinmousebrain
AT seridiloqmane characterizationofpirnasacrosspostnataldevelopmentinmousebrain
AT ryutaewoo characterizationofpirnasacrosspostnataldevelopmentinmousebrain
AT takahashihazuki characterizationofpirnasacrosspostnataldevelopmentinmousebrain
AT orlandovalerio characterizationofpirnasacrosspostnataldevelopmentinmousebrain
AT carnincipiero characterizationofpirnasacrosspostnataldevelopmentinmousebrain
AT ravasitimothy characterizationofpirnasacrosspostnataldevelopmentinmousebrain

Ejemplares similares